Frontiers in Pharmacology | Experimental Pharmacology and Drug Discovery

Original Research

Accepted on 16 May 2025

Molecular pharmacokinetic mechanism of quercetin-encapsulated polymeric micelles in alleviating cisplatin-induced nephrotoxicity and enhancing antineoplastic effects

in Experimental Pharmacology and Drug Discovery

Tangna Hao
Xiaokui Huo
Zhen Li
Changyuan Wang
Sha Wu
Anni Song
Fengyu Zhang
Kexin Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1590688

174 views

Original Research

Published on 16 May 2025

Discovery of non-covalent rhinovirus 3Cpro inhibitors by molecular docking, in vitro assays, molecular dynamics simulations and DFT analyses

in Experimental Pharmacology and Drug Discovery

Susu Zhang
Keli Zong
Jiajun Ruan
Xiaojing Liu
Xu Zhao
Youzhi Zhang
Chun Hu
Xingzhou Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1560571

452 views

Review

Published on 16 May 2025

Circular RNAs as disease modifiers of complex neurologic disorders

in Experimental Pharmacology and Drug Discovery

Veronica Galli
Sara Vinciguerra
Marta Biagioli
Jasmin Morandell

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1577496

510 views

Original Research

Published on 16 May 2025

Therapeutic potential of zinc 64Zn aspartate for obesity management: impact on oxidative stress, lipid metabolism, pancreas and liver in high-calorie diet model

in Experimental Pharmacology and Drug Discovery

Max Temnik
Sergey Gurin
Alexandr Balakin
Roman Byshovets
Olesia Kalmukova
Tetiana Vovk
Tetiana Halenova
Nataliia Raksha
Tetyana Falalyeyeva
Olexiy Savchuk

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1543166

586 views

Original Research

Accepted on 15 May 2025

Palmitoylation-Driven Immune Dysregulation and Prognostic Signature in low-grade glioma: A Multi-Omics and Functional Validation Study

in Experimental Pharmacology and Drug Discovery

Zehao Wang
Yufan Wu
Jingqing Hu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1586921

153 views

Editorial

Accepted on 15 May 2025

Editorial: Application of PKPD Modeling in Drug Discovery and Development

in Experimental Pharmacology and Drug Discovery

Ren Hong-can

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1614689

249 views

Opinion

Accepted on 15 May 2025

Prodrug-carboxypeptidase G2 therapy: certain concerns on carboxypeptidase G2

in Experimental Pharmacology and Drug Discovery

Tinghe Yu
Tianyan Yu
Xinya Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1560834

305 views

Original Research

Published on 15 May 2025

Nafamostat mesylate augments survival in rats afflicted by exertional heat stroke

in Experimental Pharmacology and Drug Discovery

Qingwei Lin
Zhuqing Luo
Longping He
Lincui Zhong
Qingbo Zeng
Ye Zhou
Qi Chen
Xingping Deng
Xiaomin Song
Qing Song

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1559181

431 views

Mini Review

Published on 14 May 2025

Sphingosine 1-phosphate receptor 1 modulators exert neuroprotective effects in central nervous system disorders

in Experimental Pharmacology and Drug Discovery

Shouming Chen
Lan Wu
Bingchen Lang
Guoyan Zhao
Wensheng Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1516991

645 views

Review

Published on 14 May 2025

Natural products for anti-fibrotic therapy in idiopathic pulmonary fibrosis: marine and terrestrial insights

in Experimental Pharmacology and Drug Discovery

Meiting Ma
Zhengqi Chu
Hongyu Quan
Hanxu Li
Yuran Zhou
Yanhong Han
Kefeng Li
Wenjun Pan
De-Yun Wang
Yan Yan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1524654

855 views

Original Research

Published on 14 May 2025

Bioactive fraction isolated from Curcuma angustifolia rhizome exerts anti-diabetic effects in vitro, in silico and in vivo by regulating AMPK/PKA signaling pathway

in Experimental Pharmacology and Drug Discovery

P. Kavya
M. Gayathri

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1570533

623 views

Review

Published on 14 May 2025

Biosynthesis of silver nanoparticles from plant extracts: a comprehensive review focused on anticancer therapy

in Experimental Pharmacology and Drug Discovery

Pratibha Pandey
Sorabh Lakhanpal
Ashok Kumar Bishoyi
S. Renuka Jyothi
Swati Mishra
Meenakshi Verma
Ajay Singh
Mir Waqas Alam
Safia Obaidur Rab
Mohd Saeed

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1600347

841 views

Original Research

Published on 14 May 2025

Cardiomyocyte-derived exosomes carrying miR-181a-5p facilitate heart-brain crosstalk and exacerbate methamphetamine dependence in rats

in Experimental Pharmacology and Drug Discovery

Hancheng Li
Yongen Peng
Yangkai Wu
Yiling Chen
Jieyu Li
Yunbing He
Hongwu Wang
Chaohua Luo
Zhixian Mo

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1541442

498 views

Original Research

Published on 14 May 2025

Integrating network pharmacology, quantitative transcriptomic analysis, and experimental validation revealed the mechanism of cordycepin in the treatment of obesity

in Experimental Pharmacology and Drug Discovery

Yu Liao
Mingchao Wang
Fuli Qin
Taotao Liu
Jiemei Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1571480

628 views

Original Research

Accepted on 13 May 2025

Design and Screening of Novel 1,2,4-Triazole-3-thione Derivatives as DCN1 Inhibitors for Anticardiac Fibrosis Based on 3D-QSAR Modeling and Molecular Dynamics

in Experimental Pharmacology and Drug Discovery

Wengong Bian
YaXin Guo

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1590711

146 views

Original Research

Accepted on 13 May 2025

The anti-depressive role of the Pei Yuan Kai Yu formula in cerebral small vessel disease based on gut microbiota

in Experimental Pharmacology and Drug Discovery

Lixuan Yang
Yutian Ao
Yannan Li
Baoan Dai
Junnan Li
Wenzhe Duan
Kaiqiang Dong
Zhenyun Han
Rongjuan Guo

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1510250