Frontiers in Pharmacology | Gastrointestinal and Hepatic Pharmacology

Review

Published on 19 May 2025

Insights into the gut-liver axis: mechanisms and emerging therapies in hepatocellular carcinoma

in Gastrointestinal and Hepatic Pharmacology

Yongjian Hu
Mingming Gao
Jiajin Chenghuang
Rui Bao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1595853

4,365 views
2 citations

Original Research

Published on 16 May 2025

2-Dodecyl-6-methoxycyclohexa-2,5-dien-1,4-dione alleviates liver fibrosis and improves intestinal flora and bile acid metabolism

in Gastrointestinal and Hepatic Pharmacology

Yongfei He
Thi Thai Hoa Pham
Junming Xu
Shengjie Hong
Jicai Wang
Hang Zhai
Qiang Tao
Ruixi Li
Guangquan Zhang
Xianjie Shi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1581138

2,042 views

Original Research

Published on 15 May 2025

Pan-cancer profiling of FZD2 as a prognostic biomarker: integrative multi-omics analysis with experimental validation and functional characterization in gastric cancer

in Gastrointestinal and Hepatic Pharmacology

Sijiang Zhou
Da Li
Chao Quan
Zhu Yu
Yue Feng
Shengyu Wang
Yong Li
Tongtong Qi
Junqiang Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1534974

4,307 views

Original Research

Published on 13 May 2025

First-line treatment of hepatocellular carcinoma: a propensity-matched analysis of tyrosine kinase inhibitors combined with TACE, with or without PD-1 inhibitors

in Gastrointestinal and Hepatic Pharmacology

Yanjun Shen
Yawen Xu
Ying Teng
Xiaoyan Ding
Jinglong Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1533471

1,578 views

Mini Review

Published on 12 May 2025

Effect of Diquat on gut health: molecular mechanisms, toxic effects, and protective strategies

in Gastrointestinal and Hepatic Pharmacology

Cheng He
Guorong Cai
Yingmao Jia
Rong Jiang
Xiaolan Wei
Ning Tao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1562182

13,154 views
2 citations

Review

Published on 12 May 2025

Mucoprotectants and gut barrier: mechanisms of action and clinical applications in IBS. Is there a possible role?

in Gastrointestinal and Hepatic Pharmacology

Francesco Rettura
Christian Lambiase
Riccardo Tedeschi
Antonio Grosso
Lorenzo Cancelli
Angelo Ricchiuti
Andrea Bottari
Luca Giacomelli
Nicola de Bortoli
Massimo Bellini

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1538791

3,219 views
1 citation

Review

Published on 08 May 2025

Knowledge landscape of macrophage research in liver fibrosis: a bibliometric review of the literature from WoSCC

in Gastrointestinal and Hepatic Pharmacology

Yanbo Li
Zhengmin Cao
Yanping Lu
Chao Lei
Wenliang Lyu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1571879

2,993 views

Original Research

Published on 08 May 2025

Metformin improves intestinal ischemia-reperfusion injury by reducing the formation of mitochondrial associated endoplasmic reticulum membranes (MAMs) and inhibiting ferroptosis in intestinal cells

in Gastrointestinal and Hepatic Pharmacology

Xu Zhao
Likun Yan
Lifei Tian
Xiaolong Zhang
Ruiting Liu
Zeyu Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1581085

2,992 views
3 citations

Original Research

Published on 06 May 2025

Pachymic acid alleviates metabolic dysfunction-associated steatotic liver disease by inhibiting ferroptosis through PPARα

in Gastrointestinal and Hepatic Pharmacology

Guilin Ren
Yiyou Lin
Jiannan Qiu
Congcong Zhang
Lin Chen
Linwensi Zhu
Xiaohui Fan
Xiaobing Dou
Qingsheng Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1554850

2,953 views
2 citations

Systematic Review

Published on 30 Apr 2025

Assessing the therapeutic potential of rutin in alleviating symptoms of inflammatory bowel disease: a meta-analysis

in Gastrointestinal and Hepatic Pharmacology

Zhenkai Zou
Fanglian Zhang
Zhigang Pan
Jinyao Xu
Xuanyi Li
Xiangjun Sun
Xufeng Wang
Feng Qin
Abulikemu Abulizi
Qian Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1539469

2,609 views
2 citations

Original Research

Published on 30 Apr 2025

Albiflorin inhibits inflammation to improve liver fibrosis by targeting the CXCL12/CXCR4 axis in mice

in Gastrointestinal and Hepatic Pharmacology

Lingjie Meng
Huijing Lv
Anli Liu
Qian Cao
Xinyi Du
Chengjin Li
Qinggui Li
Qingqing Luo
Yi Xiao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1577201

2,948 views
1 citation

Original Research

Published on 30 Apr 2025

Resveratrol targeting MDM2/P53/PUMA axis to inhibit colonocyte apoptosis in DSS-induced ulcerative colitis mice

in Gastrointestinal and Hepatic Pharmacology

Rui Tang
Ling Jiang
Quan Ji
Pengyuan Kang
Yuan Liu
Pengyu Miao
Xiaofan Xu
Mingxi Tang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1572906

3,248 views
2 citations

Original Research

Published on 29 Apr 2025

Proton pump inhibitors use and risk of type 2 diabetes mellitus: correlation analysis, prediction model construction, and key genes identification

in Gastrointestinal and Hepatic Pharmacology

Cuilv Liang
Yin Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1580090

4,118 views
1 citation

Review

Published on 28 Apr 2025

Gastrointestinal injury in cardiopulmonary bypass: current insights and future directions

in Gastrointestinal and Hepatic Pharmacology

Qi-Long Mao
Zi-Hang Yu
Liang Nie
Fei-Xiang Wang
Yu-Hui Dong
Xiao-Fei Qi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1542995

2,269 views
1 citation

Original Research

Published on 28 Apr 2025

Resveratrol and N-acetylcystein reduce hepatic steatosis but enhance initiation and progression of hepatocellular carcinoma by inhibiting GST-pi-MAPK axis in mice

in Gastrointestinal and Hepatic Pharmacology

Mi Zhang
Weigang Yuan
Chun Li
Chanyuan Chen
Xiang Liu
Zhilu Ma
Yifei Xiang
Guisha Chen
Chunxu Wang
Lei Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1574039

2,813 views
1 citation

Systematic Review

Published on 28 Apr 2025

Efficacy and safety of IL-23 p19 inhibitors in the treatment for inflammatory bowel disease: a systematic review and meta-analysis

in Gastrointestinal and Hepatic Pharmacology

Shuhan Wang
Hui Sun
Qian Wang
Han Xiao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1490667

5,037 views
4 citations