Frontiers in Pharmacology | Predictive Toxicology

Original Research

Published on 07 Dec 2021

Five Constituents Contributed to the Psoraleae Fructus-Induced Hepatotoxicity via Mitochondrial Dysfunction and Apoptosis

in Predictive Toxicology

Zhaojuan Guo
Pin Li
Chunguo Wang
Qianjun Kang
Can Tu
Bingqian Jiang
Jingxuan Zhang
Weiling Wang
Ting Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2021.682823

6,219 views
34 citations

Original Research

Published on 25 Nov 2021

Excretion and Residual Concentration Correlations of Salbutamol Between Edible Tissues and Living Samples in Pigs and Goats

in Predictive Toxicology

Lei Sun
Minjuan Zhu
Jingfei Shi
Kun Mi
Wenjing Ma
Xiangyue Xu
Hanyu Wang
Yuanhu Pan
Yanfei Tao
Zhenli Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2021.754876

3,239 views
2 citations

Original Research

Published on 22 Nov 2021

A Zebrafish Model of Neurotoxicity by Binge-Like Methamphetamine Exposure

in Predictive Toxicology

Juliette Bedrossiantz
Marina Bellot
Pol Dominguez-García
Melissa Faria
Eva Prats
Cristian Gómez-Canela
Raul López-Arnau
Elena Escubedo
Demetrio Raldúa

Frontiers in Pharmacology

doi 10.3389/fphar.2021.770319

6,883 views
17 citations

Original Research

Published on 12 Nov 2021

Cyclosporine A Induces Cardiac Developmental Toxicity in Zebrafish by Up-Regulation of Wnt Signaling and Oxidative Stress

in Predictive Toxicology

Mengqi Wan
Ling Huang
Jieping Liu
Fasheng Liu
Guilan Chen
Huiwen Ni
Guanghua Xiong
Xinjun Liao
Huiqiang Lu
Juhua Xiao

Frontiers in Pharmacology

doi 10.3389/fphar.2021.747991

5,285 views
21 citations

Review

Published on 12 Nov 2021

Adverse Effects and Toxicity of Immune Checkpoint Inhibitors For Patients With Urothelial Carcinoma

in Predictive Toxicology

Di Wang
Kai Sun
Tianqi Wang
Dongxu Zhang
Fengze Sun
Yuanshan Cui
Hongwei Zhao
Jitao Wu

Frontiers in Pharmacology

doi 10.3389/fphar.2021.710943

4,949 views
14 citations

Original Research

Published on 11 Nov 2021

Safety Evaluation for Restorin® NMN, a NAD+ Precursor

in Predictive Toxicology

John Turner
Albert Licollari
Emil Mihalcea
Aimin Tan

Frontiers in Pharmacology

doi 10.3389/fphar.2021.749727

15,776 views
15 citations

Original Research

Published on 10 Nov 2021

Human Health Risk Assessment of Heavy Metals and Metalloids in Herbal Medicines Used to Treat Anxiety: Monitoring of Safety

in Predictive Toxicology

Ana C. R. Geronimo
Elaine S. P. Melo
Kassia R. N. Silva
Hugo S. Pereira
Valdir A. Nascimento
David J. Machate
Valter A. do Nascimento

Frontiers in Pharmacology

doi 10.3389/fphar.2021.772928

12,002 views
33 citations

Original Research

Published on 22 Oct 2021

CircEpc1 Promotes Ricin Toxin-Induced Inflammation via Activation of NF-κB and MAPK Signaling Pathways by Sponging miR-5114

in Predictive Toxicology

Mingxin Dong
Xiaohao Zhang
Haotian Yu
Yan Wang
Ying Chang
Chengbiao Sun
Jianxu Zhang
Na Zhao
Kaikai Yu
Guangchao Sun

Frontiers in Pharmacology

doi 10.3389/fphar.2021.767900

3,192 views
6 citations

Original Research

Published on 18 Oct 2021

Evaluation of CML TKI Induced Cardiovascular Toxicity and Development of Potential Rescue Strategies in a Zebrafish Model

in Predictive Toxicology

Shan Cheng
Pan Jin
Heying Li
Duanqing Pei
Xiaodong Shu

Frontiers in Pharmacology

doi 10.3389/fphar.2021.740529

7,427 views
11 citations

Original Research

Published on 14 Oct 2021

Path4Drug: Data Science Workflow for Identification of Tissue-Specific Biological Pathways Modulated by Toxic Drugs

in Predictive Toxicology

Barbara Füzi
Jana Gurinova
Henning Hermjakob
Gerhard F. Ecker
Rahuman Sheriff

Frontiers in Pharmacology

doi 10.3389/fphar.2021.708296

6,556 views
10 citations

Original Research

Published on 27 Sep 2021

Effects of Fluoride on Submandibular Glands of Mice: Changes in Oxidative Biochemistry, Proteomic Profile, and Genotoxicity

in Predictive Toxicology

Leidiane Alencar de Oliveira Lima
Giza Hellen Nonato Miranda
Walessa Alana Bragança Aragão
Leonardo Oliveira Bittencourt
Sávio Monteiro dos Santos
Michel Platini Caldas de Souza
Lygia S. Nogueira
Edivaldo Herculano Corrêa de Oliveira
Marta Chagas Monteiro
Aline Dionizio

Frontiers in Pharmacology

doi 10.3389/fphar.2021.715394

3,679 views
13 citations

Original Research

Published on 23 Sep 2021

Carbamazepine Induces Platelet Apoptosis and Thrombocytopenia Through Protein Kinase A

in Predictive Toxicology

Weiling Xiao
Kangxi Zhou
Mengnan Yang
Chenglin Sun
Lan Dai
Jian Gu
Rong Yan
Kesheng Dai

Frontiers in Pharmacology

doi 10.3389/fphar.2021.749930

10,151 views
14 citations

Original Research

Published on 21 Sep 2021

Effects of Bisphenols on RACK1 Expression and Their Immunological Implications in THP-1 Cells

in Predictive Toxicology

Erica Buoso
Maša Kenda
Mirco Masi
Pasquale Linciano
Valentina Galbiati
Marco Racchi
Marija Sollner Dolenc
Emanuela Corsini

Frontiers in Pharmacology

doi 10.3389/fphar.2021.743991

5,925 views
36 citations

Original Research

Published on 21 Sep 2021

Toxicity Evaluation of Long-Term Topical Application of Recombinant Human Keratinocyte Growth Factor-2 Eye Drops on Macaca Fascicularis

in Predictive Toxicology

Le Li
Lijia Li
Qi Chen
Xuanxin Yang
Qi Hui
Hamdi AL-Azzani
Yadong Huang
Jianqiu Cai
Xiaojie Wang
Zi Jin

Frontiers in Pharmacology

doi 10.3389/fphar.2021.740726

3,062 views

Original Research

Published on 16 Sep 2021

Lido-OH, a Hydroxyl Derivative of Lidocaine, Produced a Similar Local Anesthesia Profile as Lidocaine With Reduced Systemic Toxicities

in Predictive Toxicology

Qinqin Yin
Weiyi Zhang
Bowen Ke
Jin Liu
Wensheng Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2021.678437

4,766 views
5 citations

Review

Published on 09 Sep 2021

Novel Methods and Approaches for Safety Evaluation of Nanoparticle Formulations: A Focus Towards In Vitro Models and Adverse Outcome Pathways

in Predictive Toxicology

Mounika Gayathri Tirumala
Pratibha Anchi
Susmitha Raja
Mahesh Rachamalla
Chandraiah Godugu

Frontiers in Pharmacology

doi 10.3389/fphar.2021.612659

18,260 views
127 citations

Original Research

Published on 02 Sep 2021

Development, Testing, Parameterisation and Calibration of a Human PBPK Model for the Plasticiser, Di-(2-propylheptyl) Phthalate (DPHP) Using in Silico, in vitro and Human Biomonitoring Data

in Predictive Toxicology

Kevin McNally
Craig Sams
Alex Hogg
Annie Lumen
George Loizou

Frontiers in Pharmacology

doi 10.3389/fphar.2021.692442

6,084 views
9 citations

Original Research

Published on 01 Sep 2021

Spermine-Related DNA Hypermethylation and Elevated Expression of Genes for Collagen Formation are Susceptible Factors for Chemotherapy-Induced Hand-Foot Syndrome in Chinese Colorectal Cancer Patients

in Predictive Toxicology

Mingming Li
Jiani Chen
Shaoqun Liu
Xiaomeng Sun
Huilin Xu
Qianmin Gao
Xintao Chen
Chaowen Xi
Doudou Huang
Yi Deng

Frontiers in Pharmacology

doi 10.3389/fphar.2021.746910

6,655 views
15 citations

Original Research

Published on 26 Aug 2021

Mogroside V Alleviates Oocyte Meiotic Defects and Quality Deterioration in Benzo(a)pyrene-Exposed Mice

in Predictive Toxicology

Lumin Sui
Ke Yan
Huiting Zhang
Junyu Nie
Xiaogan Yang
Chang-Long Xu
Xingwei Liang

Frontiers in Pharmacology

doi 10.3389/fphar.2021.722779

4,739 views
17 citations

Original Research

Published on 25 Aug 2021

Non-Lethal Concentration of MeHg Causes Marked Responses in the DNA Repair, Integrity, and Replication Pathways in the Exposed Human Salivary Gland Cell Line

in Predictive Toxicology

Lygia Sega Nogueira
Carolina P. Vasconcelos
Jessica Rodrigues Plaça
Geovanni Pereira Mitre
Leonardo Oliveira Bittencourt
Maria Sueli da Silva Kataoka
Edivaldo H. C. de Oliveira
Rafael Rodrigues Lima

Frontiers in Pharmacology

doi 10.3389/fphar.2021.698671

2,300 views

Original Research

Published on 23 Aug 2021

A Metabolic Profiling Study of Realgar-Induced Acute Kidney Injury in Mice

in Predictive Toxicology

Sheng Zhang
Chao Li
Tingting Feng
Shuai Cao
Heng Zhou
Limin Li
Qing Hu
Xiuhong Mao
Shen Ji

Frontiers in Pharmacology

doi 10.3389/fphar.2021.706249

3,897 views
14 citations

Original Research

Published on 19 Aug 2021

Dynamic Modeling of Mitochondrial Membrane Potential Upon Exposure to Mitochondrial Inhibitors

in Predictive Toxicology

Huan Yang
Wanda van der Stel
Randy Lee
Caroline Bauch
Sam Bevan
Paul Walker
Bob van de Water
Erik H. J. Danen
Joost B. Beltman

Frontiers in Pharmacology

doi 10.3389/fphar.2021.679407

9,223 views
22 citations

Review

Published on 13 Aug 2021

Toxicity of Immune-Checkpoint Inhibitors in Hematological Malignancies

in Predictive Toxicology

Katarina Hradska
Roman Hajek
Tomas Jelinek

Frontiers in Pharmacology

doi 10.3389/fphar.2021.733890

6,354 views
16 citations

Original Research

Published on 12 Aug 2021

Quantitative Structure-Activity Relationship Modeling of the Amplex Ultrared Assay to Predict Thyroperoxidase Inhibitory Activity

in Predictive Toxicology

Domenico Gadaleta
Luca d’Alessandro
Marco Marzo
Emilio Benfenati
Alessandra Roncaglioni

Frontiers in Pharmacology

doi 10.3389/fphar.2021.713037

4,214 views
11 citations

496 articles

articles

Five Constituents Contributed to the Psoraleae Fructus-Induced Hepatotoxicity via Mitochondrial Dysfunction and Apoptosis

Excretion and Residual Concentration Correlations of Salbutamol Between Edible Tissues and Living Samples in Pigs and Goats

A Zebrafish Model of Neurotoxicity by Binge-Like Methamphetamine Exposure

Cyclosporine A Induces Cardiac Developmental Toxicity in Zebrafish by Up-Regulation of Wnt Signaling and Oxidative Stress

Adverse Effects and Toxicity of Immune Checkpoint Inhibitors For Patients With Urothelial Carcinoma

Safety Evaluation for Restorin® NMN, a NAD+ Precursor

Human Health Risk Assessment of Heavy Metals and Metalloids in Herbal Medicines Used to Treat Anxiety: Monitoring of Safety

CircEpc1 Promotes Ricin Toxin-Induced Inflammation via Activation of NF-κB and MAPK Signaling Pathways by Sponging miR-5114

Evaluation of CML TKI Induced Cardiovascular Toxicity and Development of Potential Rescue Strategies in a Zebrafish Model

Path4Drug: Data Science Workflow for Identification of Tissue-Specific Biological Pathways Modulated by Toxic Drugs

Effects of Fluoride on Submandibular Glands of Mice: Changes in Oxidative Biochemistry, Proteomic Profile, and Genotoxicity

Carbamazepine Induces Platelet Apoptosis and Thrombocytopenia Through Protein Kinase A

Effects of Bisphenols on RACK1 Expression and Their Immunological Implications in THP-1 Cells

Toxicity Evaluation of Long-Term Topical Application of Recombinant Human Keratinocyte Growth Factor-2 Eye Drops on Macaca Fascicularis

Lido-OH, a Hydroxyl Derivative of Lidocaine, Produced a Similar Local Anesthesia Profile as Lidocaine With Reduced Systemic Toxicities

Novel Methods and Approaches for Safety Evaluation of Nanoparticle Formulations: A Focus Towards In Vitro Models and Adverse Outcome Pathways

Development, Testing, Parameterisation and Calibration of a Human PBPK Model for the Plasticiser, Di-(2-propylheptyl) Phthalate (DPHP) Using in Silico, in vitro and Human Biomonitoring Data

Spermine-Related DNA Hypermethylation and Elevated Expression of Genes for Collagen Formation are Susceptible Factors for Chemotherapy-Induced Hand-Foot Syndrome in Chinese Colorectal Cancer Patients

Mogroside V Alleviates Oocyte Meiotic Defects and Quality Deterioration in Benzo(a)pyrene-Exposed Mice

Non-Lethal Concentration of MeHg Causes Marked Responses in the DNA Repair, Integrity, and Replication Pathways in the Exposed Human Salivary Gland Cell Line

A Metabolic Profiling Study of Realgar-Induced Acute Kidney Injury in Mice

Dynamic Modeling of Mitochondrial Membrane Potential Upon Exposure to Mitochondrial Inhibitors

Toxicity of Immune-Checkpoint Inhibitors in Hematological Malignancies

Quantitative Structure-Activity Relationship Modeling of the Amplex Ultrared Assay to Predict Thyroperoxidase Inhibitory Activity