AUTHOR=Appiah Raymond Fosu , Jin Zhen , Yang Junyuan , Asamoah Joshua Kiddy K. 

TITLE=Cost–benefit analysis of the COVID-19 vaccination model incorporating different infectivity reductions

JOURNAL=Frontiers in Physics

VOLUME=Volume 12 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/physics/articles/10.3389/fphy.2024.1383357

DOI=10.3389/fphy.2024.1383357

ISSN=2296-424X

ABSTRACT=<p>The spread and control of coronavirus disease 2019 (COVID-19) present a worldwide economic and medical burden to public health. It is imperative to probe the effect of vaccination and infectivity reductions in minimizing the impact of COVID-19. Therefore, we analyze a mathematical model incorporating different infectivity reductions. This work provides the most economical and effective control methods for reducing the impact of COVID-19. Using data from Ghana as a sample size, we study the sensitivity of the parameters to estimate the contributions of the transmission routes to the effective reproduction number <inline-formula id="inf1"><mml:math id="m1" xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:msub><mml:mrow><mml:mtext> </mml:mtext><mml:mi>R</mml:mi></mml:mrow><mml:mi>e</mml:mi></mml:msub><mml:mo>.</mml:mo></mml:mrow></mml:math></inline-formula> We also devise optimal interventions with cost–benefit analysis that aim to maximize outcomes while minimizing COVID-19 incidences by deploying cost-effectiveness and optimization techniques. The outcomes of this work contribute to a better understanding of COVID-19 epidemiology and provide insights into implementing interventions needed to minimize the COVID-19 burden in similar settings worldwide.</p>