AUTHOR=Appiah Raymond Fosu , Jin Zhen , Yang Junyuan , Asamoah Joshua Kiddy K. TITLE=Costā€“benefit analysis of the COVID-19 vaccination model incorporating different infectivity reductions JOURNAL=Frontiers in Physics VOLUME=Volume 12 - 2024 YEAR=2024 URL=https://www.frontiersin.org/journals/physics/articles/10.3389/fphy.2024.1383357 DOI=10.3389/fphy.2024.1383357 ISSN=2296-424X ABSTRACT=The spread and control of COVID-19 is a worldwide economical and medical burden to public health. It is imperative to probe the effect of vaccination and infectivity reductions in minimizing the impact of COVID-19. Therefore, we analyze a mathematical model incorporating different infectivity reductions. This work provides the most economical and effective control methods in reducing the impact of COVID-19. Using data from Ghana as a sample size, we study the sensitivity of the parameters to estimate contributions of the transmission routes to the effective reproduction number š¯‘… š¯‘’ . We also devise optimal interventions with cost-benefit analysis that aim to maximize outcomes while minimizing COVID-19 incidences by deploying cost-effectiveness, and optimization techniques. The outcomes of this work contribute to a better understanding COVID-19 epidemiology and provide insights into implementing interventions needed to minimize COVID-19 burden in similar settings worldwide.