AUTHOR=Saito Kaori , Nakamura Nobuhiro , Ito Yusuke , Hoshijima Kazuyuki , Esaki Masahiro , Zhao Boqiang , Hirose Shigehisa TITLE=Identification of Zebrafish Fxyd11a Protein that is Highly Expressed in Ion-Transporting Epithelium of the Gill and Skin and its Possible Role in Ion Homeostasis JOURNAL=Frontiers in Physiology VOLUME=Volume 1 - 2010 YEAR=2010 URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2010.00129 DOI=10.3389/fphys.2010.00129 ISSN=1664-042X ABSTRACT=
FXYD proteins, small single-transmembrane proteins, have been proposed to be auxiliary regulatory subunits of Na+–K+-ATPase and have recently been implied in ion osmoregulation of teleost fish. In freshwater (FW) fish, numerous ions are actively taken up through mitochondrion-rich cells (MRCs) of the gill and skin epithelia, using the Na+ electrochemical gradient generated by Na+–K+-ATPase. In the present study, to understand the molecular mechanism for the regulation of Na+–K+-ATPase in MRCs of FW fish, we sought to identify FXYD proteins expressed in MRCs of zebrafish. Reverse-transcriptase PCR studies of adult zebrafish tissues revealed that, out of eight