AUTHOR=Valluru Manoj , Staton Carolyn A., Reed Malcolm W., Brown Nicola J.

TITLE=Transforming Growth Factor-β and Endoglin Signaling Orchestrate Wound Healing

JOURNAL=Frontiers in Physiology

VOLUME=volume 2 - 2011

YEAR=2011

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2011.00089

DOI=10.3389/fphys.2011.00089

ISSN=1664-042X

ABSTRACT=Various complex signalling networks, biomechanical forces and biochemical signalling pathways in both hypoxic and non-hypoxic conditions orchestrate wound healing. Endoglin is a functional marker, a type III coreceptor for transforming growth factor (TGF-β) and an important regulator of tissue repair. Endoglin is expressed in stem cells and proliferating endothelial cells with elevated expression during hypoxia, regulating cellular functions such as proliferation and cell adhesion via Smad signalling.  This review focuses on how the TGF- β family and more specifically Endoglin, regulate stem cell availability and modulate cellular behaviour within the wound microenvironment.