AUTHOR=Boucher Joshua M., Gridley Thomas , Liaw Lucy 

TITLE=Molecular Pathways of Notch Signaling in Vascular Smooth Muscle Cells

JOURNAL=Frontiers in Physiology

VOLUME=3

YEAR=2012

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2012.00081

DOI=10.3389/fphys.2012.00081

ISSN=1664-042X

ABSTRACT=<p>Notch signaling in the cardiovascular system is important during embryonic development, vascular repair of injury, and vascular pathology in humans. The vascular smooth muscle cell (VSMC) expresses multiple Notch receptors throughout its life cycle, and responds to Notch ligands as a regulatory mechanism of differentiation, recruitment to growing vessels, and maturation. The goal of this review is to provide an overview of the current understanding of the molecular basis for Notch regulation of VSMC phenotype. Further, we will explore Notch interaction with other signaling pathways important in VSMC.</p>