AUTHOR=Sellers Stephanie L., Trane Andy , Bernatchez Pascal N.

TITLE=Caveolin as a potential drug target for cardiovascular protection

JOURNAL=Frontiers in Physiology

VOLUME=Volume 3 - 2012

YEAR=2012

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2012.00280

DOI=10.3389/fphys.2012.00280

ISSN=1664-042X

ABSTRACT=Caveolae and caveolin are key players in a number of disease processes. Current research indicates that caveolins play a significant role in cardiovascular disease and dysfunction. The far-reaching roles of caveolins in disease and dysfunction make them particularly notable therapeutic targets. In particular, caveolin-1 and caveolin-3 have been identified as potential regulators of vascular dysfunction and heart disease, and might even confer cardiac protection in certain settings. Such a central role in vascular health therefore makes manipulation of caveolin-1/3 function or expression levels clear therapeutic targets in a variety of cardiovascular related disease states. Here, we highlight the role of caveolin-1 and -3 in cardiovascular health and explore the potential of caveolin-1 and caveolin-3 derived experimental therapeutics.