AUTHOR=Lira Fabio Santos , dos Santos Thaislaine , Caldeira Renan Santos , Inoue Daniela S. , Panissa Valéria L. G. , Cabral-Santos Carolina , Campos Eduardo Z. , Rodrigues Bruno , Monteiro Paula A. 

TITLE=Short-Term High- and Moderate-Intensity Training Modifies Inflammatory and Metabolic Factors in Response to Acute Exercise

JOURNAL=Frontiers in Physiology

VOLUME=8

YEAR=2017

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2017.00856

DOI=10.3389/fphys.2017.00856

ISSN=1664-042X

ABSTRACT=<p><bold>Purpose:</bold> To compare the acute and chronic effects of high intensity intermittent training (HIIT) and steady state training (SST) on the metabolic profile and inflammatory response in physically active men.</p><p><bold>Methods:</bold> Thirty recreationally active men were randomly allocated to a control group (<italic>n</italic> = 10), HIIT group (<italic>n</italic> = 10), or SST group (<italic>n</italic> = 10). For 5 weeks, three times per week, subjects performed HIIT (5 km 1-min at 100% of maximal aerobic speed interspersed by 1-min passive recovery) or SST (5 km at 70% of maximal aerobic speed) while the control group did not perform training. Blood samples were collected at fasting (~12 h), pre-exercise, immediately post, and 60 min post-acute exercise session (pre- and post-5 weeks training). Blood samples were analyzed for glucose, non-ester fatty acid (NEFA), and cytokine (IL-6, IL-10, and TNF-α) levels through a three-way analysis (group, period, and moment of measurement) with repeated measures in the second and third factors.</p><p><bold>Results:</bold> The results showed an effect of moment of measurement (acute session) with greater values to TNF-α and glucose immediately post the exercise when compared to pre exercise session, independently of group or training period. For IL-6 there was an interaction effect for group and moment of measurement (acute session) the increase occurred immediately post-exercise session and post-60 min in the HIIT group while in the SST the increase was observed only 60 min post, independently of training period. For IL-10, there was an interaction for training period (pre- and post-training) and moment of measurement (acute session), in which in pre-training, pre-exercise values were lower than immediately and 60 min post-exercise, in post-training period pre-exercise values were lower than immediately post-exercise and immediately post-exercise lower than 60 min post, it was also observed that values immediately post-exercise were lower pre- than post-training, being all results independently of intensity (group).</p><p><bold>Conclusion:</bold> Our main result point to an interaction (acute and chronic) for IL-10 showing attenuation post-training period independent of exercise intensity.</p>