AUTHOR=Ramakrishnan Latha , Pedersen Sofia L. , Toe Quezia K. , Quinlan Gregory J. , Wort Stephen J. 

TITLE=Pulmonary Arterial Hypertension: Iron Matters

JOURNAL=Frontiers in Physiology

VOLUME=Volume 9 - 2018

YEAR=2018

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2018.00641

DOI=10.3389/fphys.2018.00641

ISSN=1664-042X

ABSTRACT=The interplay between iron and oxygen is longstanding and central to all aerobic life. Tight regulation of these interactions including homeostatic regulation of iron utilisation ensures safe usage of this limited resource. However, when control is lost adverse events can ensue, which are known to contribute to an array of disease processes. Recently, associations between disrupted iron homeostasis and pulmonary artery hypertension (PAH) have been described with the suggestion that there is a contributory link with the disease process. This review seeks to highlight this literature and suggests the potential for therapeutic options to restore iron homeostatic balance in PAH.