AUTHOR=Radwański Przemysław B. , Johnson Christopher N. , Györke Sándor , Veeraraghavan Rengasayee 

TITLE=Cardiac Arrhythmias as Manifestations of Nanopathies: An Emerging View

JOURNAL=Frontiers in Physiology

VOLUME=Volume 9 - 2018

YEAR=2018

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2018.01228

DOI=10.3389/fphys.2018.01228

ISSN=1664-042X

ABSTRACT=Through ongoing research, we are beginning to appreciate that cardiomyocyte nanodomains constitute the functional units for the essential processes of cardiac physiology such as electrical impulse propagation and excitation-contraction coupling. Furthermore, we are recognizing nanodomain dysfunction as the fundamental process underlying life-threatening arrhythmias in a variety of pathologies. Here, we offer an overview of current research on the role of nanodomains in cardiac physiology with particular emphasis on: 1. sodium channel-rich nanodomains within the intercalated disk that participate in cell-to-cell electrical coupling, and 2. dyadic nanodomains located along transverse tubules that participate in excitation-contraction coupling.