AUTHOR=Skogestad Jonas , Aronsen Jan Magnus 

TITLE=Hypokalemia-Induced Arrhythmias and Heart Failure: New Insights and Implications for Therapy

JOURNAL=Frontiers in Physiology

VOLUME=Volume 9 - 2018

YEAR=2018

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2018.01500

DOI=10.3389/fphys.2018.01500

ISSN=1664-042X

ABSTRACT=Routine use of diuretics and neurohumoral activation make hypokalemia (serum K+< 3.5 mM) a prevalent electrolyte disorder among heart failure patients, contributing to the increased risk of ventricular arrhythmias and sudden cardiac death in heart failure. Recent experimental studies suggest that hypokalemia-induced arrhythmias are initiated by reduced activity in the Na+/K+-ATPase (NKA), subsequently leading to Ca2+ overload, Ca2+/Calmodulin dependent kinase II (CaMKII) activation and development of afterdepolarizations.  In this article, we review the current evidence of mechanisms for hypokalemia-induced triggered arrhythmias, and how molecular changes in heart failure might lower the threshold for these arrhythmias. Finally, we discuss how the recent new insights in hypokalemia-