AUTHOR=Niu Yu-Ming , Wang Ya-Dong , Jiang Guang-Bin , Bai Gang , Chai Hong-Bo , Li Xue-Feng , Hu Yuan-Yuan , Shen Ming 

TITLE=Association Between Vitamin D Receptor Gene Polymorphisms and Polycystic Ovary Syndrome Risk: A Meta-Analysis

JOURNAL=Frontiers in Physiology

VOLUME=Volume 9 - 2018

YEAR=2019

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2018.01902

DOI=10.3389/fphys.2018.01902

ISSN=1664-042X

ABSTRACT=Objective: Published studies have demonstrated a closer association between vitamin D receptor (VDR) gene polymorphisms and polycystic ovary syndrome (PCOS) risk, but the results were inconsistent. We therefore performed this meta-analysis to explore the precise associations between VDR gene polymorphisms and PCOS risk. 
Methods: Five online electronic databases (PubMed, Embase, SCI index, CNKI and Wanfang) were searched. Odds ratios (ORs) with 95% confidence interval (CIs) were calculated to assess the association between VDR Fok I C/T (rs10735810), BsmI A/G (rs1544410), ApaI A/C (rs7975232) and TaqI T/C (rs731236) polymorphisms and PCOS risk. In addition, heterogeneity, accumulative/sensitivity analysis and publication bias were conducted to check the statistical power. 
Results: Overall, 10 publications (31 independent case-control studies) involving 1,531 patients and 1,174 controls were identified. We found that the C mutation of ApaI A/C was a risk factor for PCOS (C vs. A: OR=1.20, 95%CI=1.06-1.35, P<0.01, I2=29.7%; CC vs. AA: OR=1.49, 95%CI=1.17-1.91, P<0.01, I2=0%; CC vs. AA+AC: OR=1.36, 95%CI= 1.09-1.69, P=0.01, I2=12.8%). Moreover, the BsmI A/G polymorphism also showed a dangerous risk for PCOS in Asian population (G vs. A: OR=1.62, 95%CI=1.24-2.11, P<0.01, I2=0%; AG vs. AA: OR=2.08, 95%CI=1.26-3.20, P<0.01, I2=0%; GG vs. AA: OR=2.21, 95%CI=1.29-3.77, P<0.01, I2=0%; AG+GG vs. AA: OR=2.12, 95%CI=1.42-3.16, P<0.01, I2=0%). In addition, no significant association of Fok I C/T, and TaqI T/C polymorphisms was observed.
Conclusions: In summary, our meta-analysis suggested that VDR gene polymorphisms contribute to PCOS development, especially in Asian populations.