AUTHOR=Jiang Huali , Jiang Hualong , Zhang Jian , Chen Weijie , Luo Changyou , Li Heng , Hau William , Chen Benfa , Wang Shanhua 

TITLE=The Serum Metabolic Biomarkers in Early Diagnosis and Risk Stratification of Acute Coronary Syndrome

JOURNAL=Frontiers in Physiology

VOLUME=Volume 11 - 2020

YEAR=2020

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2020.00776

DOI=10.3389/fphys.2020.00776

ISSN=1664-042X

ABSTRACT=Despite advances in the treatment of coronary diseases, acute coronary syndrome (ACS) remains the leading cause of death worldwide. ACS is associated with metabolic abnormalities of lipid oxidation stress. In this study, based on liquid chromatograph mass spectrometry technique, we conducted the metabolic profiling analysis of serum samples from stable plaques (SPs) and vulnerable plaques (VPs) in ACS patients for exploring the potential biomarkers of plaque stability. The results showed that four differential metabolites were identified between the SPs and VPs, including betaine, acetylcarnitine, 1-heptadecanoyl-sn-glycero-3-phosphocholine and isoundecylic acid. Meanwhile, the diagnostic model was identified using stepwise logistic regression and internally validated with 10-fold cross validation. We analyzed the correlations between serum metabolic perturbations and plaque stability and the serum betaine and ejection fraction based model was estabilished with a good diagnostic efficacy (AUC = 0.808, sensitivity = 70.6%, and specificity = 80.0%). In summary, we firstly illustrate the comprehensive serum metabolic profiles in ACS patients, suggesting that the combine model of serum betaine and ejection fraction seem to be used as the potential diagnostic biomarkers for vulnerability of plaque stability.