AUTHOR=Guo Bei , Zhuang Tongtian , Xu Feng , Lin Xiao , Li Fuxingzi , Shan Su-Kang , Wu Feng , Zhong Jia-Yu , Wang Yi , Zheng Ming-Hui , Xu Qiu-Shuang , Ehsan Ullah Muhammad Hasnain , Yuan Ling-Qing 

TITLE=New Insights Into Implications of CTRP3 in Obesity, Metabolic Dysfunction, and Cardiovascular Diseases: Potential of Therapeutic Interventions

JOURNAL=Frontiers in Physiology

VOLUME=Volume 11 - 2020

YEAR=2020

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2020.570270

DOI=10.3389/fphys.2020.570270

ISSN=1664-042X

ABSTRACT=Adipose tissue, as the largest endocrine organ, secrets many biologically active molecules circulating in bloodstream, collectively termed adipocytokines which not only regulate the metabolism but also function in many pathophysiology processes. C1q tumor necrosis factor-related protein 3 (CTRP3), a novel members of CTRPs, belongs to adiponectin’s paralogs. CTRP3 has the wide-ranging effects on the glucose/lipid metabolism, inflammation response, and contributes to cardiovascular protection. In this review, we have comprehensively discussed the latest research of CTRP3 in obesity, diabetes, metabolic syndrome and cardiovascular diseases.