AUTHOR=Dong Caijuan , Wang Ya , Ma Aiqun , Wang Tingzhong 

TITLE=Life Cycle of the Cardiac Voltage-Gated Sodium Channel NaV1.5

JOURNAL=Frontiers in Physiology

VOLUME=11

YEAR=2020

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2020.609733

DOI=10.3389/fphys.2020.609733

ISSN=1664-042X

ABSTRACT=<p>Cardiac voltage-gated sodium channel Na<sub>V</sub>1.5, encoded by <italic>SCN5A</italic>, is crucial for the upstroke of action potential and excitation of cardiomyocytes. Na<sub>V</sub>1.5 undergoes complex processes before it reaches the target membrane microdomains and performs normal functions. A variety of protein partners are needed to achieve the balance between <italic>SCN5A</italic> transcription and mRNA decay, endoplasmic reticulum retention and export, Golgi apparatus retention and export, selective anchoring and degradation, activation, and inactivation of sodium currents. Subtle alterations can impair Na<sub>V</sub>1.5 in terms of expression or function, eventually leading to Na<sub>V</sub>1.5-associated diseases such as lethal arrhythmias and cardiomyopathy.</p>