AUTHOR=Hayase Kazuma , Kainuma Atsushi , Akiyama Koichi , Kinoshita Mao , Shibasaki Masayuki , Sawa Teiji 

TITLE=Poincaré Plot Area of Gamma-Band EEG as a Measure of Emergence From Inhalational General Anesthesia

JOURNAL=Frontiers in Physiology

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2021.627088

DOI=10.3389/fphys.2021.627088

ISSN=1664-042X

ABSTRACT=<p>The Poincaré plot obtained from electroencephalography (EEG) has been used to evaluate the depth of anesthesia. A standalone EEG Analyzer application was developed; raw EEG signals obtained from a bispectral index (BIS) monitor were analyzed using an on-line monitoring system. Correlations between Poincaré plot parameters and other measurements associated with anesthesia depth were evaluated during emergence from inhalational general anesthesia. Of the participants, 20 were adults anesthetized with sevoflurane (adult<sub>_<italic>S</italic><italic>E</italic><italic>V</italic></sub>), 20 were adults anesthetized with desflurane (adult<sub>_<italic>D</italic><italic>E</italic><italic>S</italic></sub>), and 20 were pediatric patients anesthetized with sevoflurane (ped<sub>_<italic>S</italic><italic>E</italic><italic>V</italic></sub>). EEG signals were preprocessed through six bandpass digital filters (f0: 0.5–47 Hz, f1: 0.5–8 Hz, f2: 8–13 Hz, f3: 13–20 Hz, f4: 20–30 Hz, and f5: 30–47 Hz). The Poincaré plot-area ratio (PP<sub>AR</sub> = PP<sub><italic>A_fx</italic></sub>/PP<sub><italic>A_f0</italic></sub>, fx = f1∼f5) was analyzed at five frequency ranges. Regardless of the inhalational anesthetic used, there were strong linear correlations between the logarithm of PP<sub><italic>AR</italic></sub> at f5 and BIS (<italic>R</italic><sup>2</sup> = 0.67, 0.79, and 0.71, in the adult<sub>_<italic>S</italic><italic>E</italic><italic>V</italic></sub>, adult<sub>_<italic>D</italic><italic>E</italic><italic>S</italic></sub>, and ped<sub>_<italic>S</italic><italic>E</italic><italic>V</italic></sub> groups, respectively). As an additional observation, a part of EMG activity at the gamma range of 30–47 Hz probably influenced the calculations of BIS and PP<sub><italic>AR_f5</italic></sub> with a non-negligible level. The logarithm of PP<sub>AR</sub> in the gamma band was most sensitive to state changes during the emergence process and could provide a new non-proprietary parameter that correlates with changes in BIS during measurement of anesthesia depth.</p>