AUTHOR=Gerasimova-Chechkina Evgeniya , Toner Brian C. , Batchelder Kendra A. , White Basel , Freynd Genrietta , Antipev Igor , Arneodo Alain , Khalil Andre 

TITLE=Loss of Mammographic Tissue Homeostasis in Invasive Lobular and Ductal Breast Carcinomas vs. Benign Lesions

JOURNAL=Frontiers in Physiology

VOLUME=Volume 12 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2021.660883

DOI=10.3389/fphys.2021.660883

ISSN=1664-042X

ABSTRACT=The 2D wavelet transform modulus maxima (WTMM) method is used to perform a comparison of the spatial fluctuations of mammographic breast tissue from patients with invasive lobular carcinoma, those with invasive ductal carcinoma, and those with benign lesions. We follow a procedure developed and validated in a previous study, in which a sliding window protocol is used to analyze thousands of small subregions in a given mammogram. These subregions are categorized according to their Hurst exponent values (H): fatty tissue (H≤0.45), dense tissue (H≥0.55), and disrupted tissue potentially linked with tumor-associated loss of homeostasis (0.45