AUTHOR=Moreno-Navarrete José María , Comas Ferran , de Jager Vincent , Fernández-Real José Manuel , Bouma Hjalmar R. 

TITLE=Cecal Ligation and Puncture-Induced Sepsis Promotes Brown Adipose Tissue Inflammation Without Any Impact on Expression of Thermogenic-Related Genes

JOURNAL=Frontiers in Physiology

VOLUME=Volume 12 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2021.692618

DOI=10.3389/fphys.2021.692618

ISSN=1664-042X

ABSTRACT=Background and aims: The negative effects of chronic low-level inflammation on adipose tissue physiology has been extensively demonstrated, whereas the effects of acute inflammation is less studied. Here, we aimed to investigate the effects of sepsis-induced acute inflammation on gene expression markers of brown and white adipose tissue functionality. 
Methods: Brown (BAT) and perirenal white (prWAT) adipose tissue gene expression markers were analysed in cecal ligation and puncture (CLP)-induced sepsis mice model.
Results: CLP-induced sepsis attenuated expression of adipogenesis-related genes, in parallel to increased Tnf, Il6 and Ltf gene expression in prWAT. In contrast, CLP-induced sepsis resulted in increased expression of pro-inflammatory genes (Il6, Ltf and Lbp) in BAT, without affecting expression of genes encoding for thermogenic activity.
Conclusion: Sepsis promotes both prWAT and BAT inflammation, associated with reduced adipogenesis-related gene expression in prWAT, without significant effects on BAT thermogenic genes.