AUTHOR=Li Huihui , Chen Chen , Wang Dao Wen TITLE=Inflammatory Cytokines, Immune Cells, and Organ Interactions in Heart Failure JOURNAL=Frontiers in Physiology VOLUME=12 YEAR=2021 URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2021.695047 DOI=10.3389/fphys.2021.695047 ISSN=1664-042X ABSTRACT=

Despite mounting evidence demonstrating the significance of inflammation in the pathophysiological mechanisms of heart failure (HF), most large clinical trials that target the inflammatory responses in HF yielded neutral or even worsening outcomes. Further in-depth understanding about the roles of inflammation in the pathogenesis of HF is eagerly needed. This review summarizes cytokines, cardiac infiltrating immune cells, and extracardiac organs that orchestrate the complex inflammatory responses in HF and highlights emerging therapeutic targets.