AUTHOR=Dai Qing , Xie Deqiong , Zhang Chenli , Zhu Lei , Xu Ying , Li Kui , Hao Wen , Yin Hefei 

TITLE=Osthole Blocks HMGB1 Release From the Nucleus and Confers Protective Effects Against Renal Ischemia-Reperfusion Injury

JOURNAL=Frontiers in Physiology

VOLUME=Volume 12 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2021.735425

DOI=10.3389/fphys.2021.735425

ISSN=1664-042X

ABSTRACT=Renal ischemia-reperfusion (IR) is one of the main causes of renal injury. IR-related renal damage progresses rapidly and can even lead to acute renal failure in severe cases with serious consequences. Its clinical treatment is currently difficult. According to a number of studies at home and abroad, HMGB1 is released from the nucleus into the cytoplasm or extracellular space by damaged parenchymal cells during ischemia and hypoxia, and this plays an important role in the initiation of reperfusion injury as an early inflammatory factor and is closely related to the occurrence and development of renal diseases. In recent years, the protective effect of osthole on IR of tissues and organs has been a key topic among clinical researchers. Osthole can inhibit inflammatory response, reduce cell apoptosis, and reduce the progression and improve the prognosis of IR, thus protecting the kidney. The mechanism through which osthole blocks the release of HMGB1 from the nucleus during the development of renal IR would be helpful in detecting targets for clinical treatment.