AUTHOR=Xu Qiuying , Li Shuwei , Tang Wenjie , Yan Jiayou , Wei Xiaolan , Zhou Mengjia , Diao Hui 

TITLE=The Effect of Ellagic Acid on Hepatic Lipid Metabolism and Antioxidant Activity in Mice

JOURNAL=Frontiers in Physiology

VOLUME=Volume 12 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2021.751501

DOI=10.3389/fphys.2021.751501

ISSN=1664-042X

ABSTRACT=Accumulating evidence has demonstrated that the imbalance of lipid metabolism and antioxidant capacity leads to damage to liver. The present study aimed to investigate the effects of Ellagic acid (EA), a phenolic compound, on hepatic lipid metabolism and antioxidant activity in mice. In our study, thirty-six C57BL/6J mice were divided into three groups: (1) control (CON); (2) basal diet+0.1% EA (EA1); (3) basal diet+0.3% EA (EA2). After the 14-day experiment, the liver was sampled for analysis. The results showed that 0.3% EA administration increased the liver weight. Total cholesterol (T-CHO) and Low-density lipoprotein cholesterol (LDL-C) activities decreased and High-density lipoprotein cholesterol (HDL-C) activity increased by EA supplementation. Meanwhile, dietary supplementation with EA dose-dependently decreased the acetyl-CoA carboxylase (ACC) protein abundance and increased the phospho-hormone-sensitive lipase (p-HSL), carnitine palmitoyltransferase 1B (CPT1B) and peroxisome proliferator-activated receptor alpha (PPARα) protein abundances. Moreover, EA supplementation reduced the malonaldehyde (MDA) concentration and increased the superoxide dismutase (SOD) and catalase (CAT) concentrations. The protein abundances of phospho-nuclear factor-E2-related factor 2 (p-Nrf2), heme oxygenase-1 (HO-1) and NAD(P)H: quinone oxidoreductase 1 (NQO1) increased by EA supplementation in a dose-dependent manner. Taken together, EA supplementation promoted the lipid metabolism and antioxidant capacity to maintain the liver health in mice.