AUTHOR=Londraville Richard L. , Tuttle Matthew , Liu Qin , Andronowski Janna M. 

TITLE=Endospanin Is a Candidate for Regulating Leptin Sensitivity

JOURNAL=Frontiers in Physiology

VOLUME=Volume 12 - 2021

YEAR=2022

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2021.786299

DOI=10.3389/fphys.2021.786299

ISSN=1664-042X

ABSTRACT=The hypothesis is advanced that endospanin, a highly conserved vesicle traffic protein in vertebrates, regulates leptin sensitivity in bone signaling.  Effects of leptin on bone are well-studied, but without consensus on whether increases in leptin signaling stimulate bone gain or loss.  Bone response may depend on leptin sensitivity, and endospanin is an established modulator of leptin sensitivity.  An argument is advanced to develop zebrafish models for specific leptin signaling pathways.  Zebrafish have well-developed molecular tools (e.g. CRISPR) and the advantage of non-destructive sampling of bone in the form of scales. Using these tools, experiments are described to substantiate the role of endospanin in zebrafish bone dynamics.