AUTHOR=Zhu Sipin , Xiang Chuan , Charlesworth Oscar , Bennett Samuel , Zhang Sijuan , Zhou Maio , Kujan Omar , Xu Jiake 

TITLE=The versatile roles of odontogenic ameloblast-associated protein in odontogenesis, junctional epithelium regeneration and periodontal disease

JOURNAL=Frontiers in Physiology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2022.1003931

DOI=10.3389/fphys.2022.1003931

ISSN=1664-042X

ABSTRACT=Junctionalepithelium(JE)isavitalepithelialcomponentwhichformsanattachmenttothe toothsurfaceatthegingivalsulcusbytheadhesionofproteincomplexesfromitsbasallayer.
DisruptionoftheJEisassociatedwiththedevelopmentofgingivitis,periodontaldisease,and
alveolarboneloss.Odontogenicameloblast-associated(ODAM),alsocalledAPINis
comprisedofasignalpeptideandanODAMproteinwith12putativeglycosylationsites.It
isexpressedduringodontogenesisbymaturationstageameloblastsandisincorporatedinto
theenamelmatrixduringtheformationofouterandsurfacelayerenamel.ODAM,asa
secretedproteinwhichisaccumulatedattheinterfacebetweenbasallaminaandenamel,
mediatestheadhesionoftheJEtothetoothsurface;andisinvolvedwithextracellular
signallingofWNTandARHGEF5-RhoA,aswellasintracellularsignallingofBMP-2-
BMPR-IB-ODAM.ODAMisalsofoundtobehighlyexpressedinsalivaryglandsand
appearstohaveimplicationsfortheregulationofformation,repair,andregenerationofthe
JE.Bioinformaticsandresearchdatahaveidentifiedtheanti-cancerpropertiesofODAM,
indicatingitspotentialbothasaprognosticbiomarkerandtherapeutictarget.Understanding
thebiologyofODAMwillhelptodesigntherapeuticstrategiesforjunctionalepithelium
regeneration,dentaldisordersandODAM-relateddiseases.