AUTHOR=Xing Chuan , Zhao Han , Zhang Jiaqi , He Bing 

TITLE=The Association of CYP17A1, CYP19A1, and SHBG Gene Polymorphisms in Polycystic Ovary Syndrome Susceptibility: A Systematic Review and Meta-Analysis

JOURNAL=Frontiers in Physiology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2022.741285

DOI=10.3389/fphys.2022.741285

ISSN=1664-042X

ABSTRACT=Objective: To elucidate the relationship between CYP17A1/CYP19A1/SHBG gene polymorphisms and PCOS susceptibility.
Methods: We searched multiple databases from inception to December 2020 and meta analysis was conducted to elucidate the relationship between gene polymorphisms and PCOS risk.
Results: 26 studies were included, comprising 4860 PCOS and 4043 controls. CYP17A1 rs743572 polymorphisms were found to be negatively associated with PCOS risk under dominant model (P=0.017, OR=0.83, 95%CI 0.72-0.97, I2=74.80%, Pheterogeneity=0.000) in the general population while neither CYP19A1 rs2414096 polymorphisms (P=0.578, OR=0.87, 95%CI 0.54-1.41, I2=95.90%, Pheterogeneity=0.000) nor SHBG rs6529 polymorphisms (P=0.752, OR=0.99, 95%CI 0.94-1.05, I2=60.90%, Pheterogeneity=0.012) was associated with PCOS susceptibility under dominant model in the general population.
Conclusion: CYP17A1 rs7435721 polymorphisms might be protective factors against PCOS in general populations.