AUTHOR=Gao Jingjing , Gao Rui , Li Hu , Liu Xi , Gao Pan , Du Junhua , Jiang Hui , Zhang Xiansheng 

TITLE=BGIG10116_34868: A Newly Discovered Gene Regulating Ejaculation Function

JOURNAL=Frontiers in Physiology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2022.762272

DOI=10.3389/fphys.2022.762272

ISSN=1664-042X

ABSTRACT=Ejaculation is a complex biphasic process involving a series of neurophysiological activities,such as the contraction of a large number of muscle groups and the ejaculation of semen from the urethra anterior. Due to the complexity of the process, there are many related factors which have not been fully clarified, resulting in ejaculation dysfunction. As a common ejaculation dysfunction, LPE (lifelong premature ejaculation) is a problem for many people. It is noteworthy that gene polymorphism might play an important role in the etiology of LPE. However, the quest for identifying the actual genetic loci that contribute to LPE etiology has not been successful. Due to discrepancies in the design and methods of research, the correlation of most reports were not obtained in subjective replication experiments, and the conclusions may be inconsistent. In our study, three groups of “rapid, normal and delayed ” ejaculation rats were selected based on the animal model of PE in rats and the theory of ejaculation. Among them, the rats with “rapid” ejaculation can be used to stimulate humans with PE. Subsequently, we used the rat brain tissue for whole transcriptome sequencing to screen the differential genes among the three groups. We try to identify the actual genetic loci that contribute to PE etiology and provide a theoretical basis for the targeted therapy of PE.