AUTHOR=Darooneh Amir Hossein , Kohandel Mohammad 

TITLE=Network Analysis Identifies Phase Transitions for Tumor With Interacting Cells

JOURNAL=Frontiers in Physiology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2022.865561

DOI=10.3389/fphys.2022.865561

ISSN=1664-042X

ABSTRACT=Metastasis is the process by which cancer cells acquire the capability to leave the primary tumor and travel to distant sites. Recent experiments have suggested that the epithelial-mesenchymal transition can regulate invasion and metastasis. Another possible scenario is the collective motion of cells. Recent studies have also proposed a jamming-unjamming transition for epithelial cells based on physical forces. Here, we assume that there exists a short-range chemical attraction between cancer cells and employ the Brownian dynamics to simulate the Tumor growth. Applying the network analysis, we suggest three possible phases for a given Tumor and study the transition between these phases by adjusting the attraction strength.