AUTHOR=Liu Chongbin , Yang Ming , Li Li , Luo Shilu , Yang Jinfei , Li Chenrui , Liu Huafeng , Sun Lin 

TITLE=A Glimpse of Inflammation and Anti-Inflammation Therapy in Diabetic Kidney Disease

JOURNAL=Frontiers in Physiology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2022.909569

DOI=10.3389/fphys.2022.909569

ISSN=1664-042X

ABSTRACT=Recently, in vitro and in vivo studies have demonstrated that inflammation plays an important role in the pathogenesis of diabetic kidney disease (DKD). A variety of complex pro-inflammatory cytokines and related signaling pathways were involved in the procession of DKD. In addition, some clinical anti-hyperglycemic drugs etc. alleviate the progression of DKD through its anti-inflammation function, but there currently lacks of systematic description. This review focuses on the novel pro-inflammatory signaling pathways in DKD, which conclude NF-κB signaling pathways, inflammasome activation, mtDNA release, HIF signaling pathway and AMPK signaling pathways.  We also discuss the related anti-inflammation mechanism of Metformin, Finerenone, SGLT2 inhibitors and Chinese Medicine.