AUTHOR=Mamen Asgeir , Lindberg Morten , Fredriksen Per Morten TITLE=Increase in peak oxygen uptake and Andersen test performance in children from age six to ten: The Health Oriented Pedagogical Project (HOPP) JOURNAL=Frontiers in Physiology VOLUME=Volume 13 - 2022 YEAR=2022 URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2022.976505 DOI=10.3389/fphys.2022.976505 ISSN=1664-042X ABSTRACT=The increased prevalence of non-communicable disease risk factors among children because of lack of physical activity is worrisome The Health Oriented Pedagogical Project (HOPP) was set up to combine learning activities and physical activity, thus reducing sedentariness during school time. The current study aimed to measure the longitudinal and cross-sectional development of cardio-metabolic risk factors, oxygen uptake and running performance, in children at ages six and ten. The validity of the Andersen Test (AT) in predicting V̇O2peak in these age groups was also evaluated. Eighty-six children (53 boys, 33 girls) with datasets at ages 6 and 10 years were included in the longitudinal study, while 192 children (106 boys, 86 girls) were included in the cross-sectional analysis. Oxygen uptake was measured using a metabolic analyser and maximal treadmill running, while the distance covered during the AT determined running performance. Body mass, height, and waist-to-height ratios were recorded. Multiple regression analysis was used to assess the association between oxygen uptake and running performance. The cross-sectional results did not differ significantly from the longitudinal data for oxygen uptake, running performance, and body mass. Height, body mass and waist-to-height ratio did not differ between the sexes at ages six or ten years. Boys had significantly higher peak oxygen uptake than girls at six years of age, irrespective of how oxygen uptake was expressed. Allometric scaling of oxygen uptake revealed differences between sexes at both ages. Longitudinal running performance increased in both sexes from six to ten years. Boys ran significantly longer at age ten but not at age six. The association between oxygen uptake and running performance varied according to how the oxygen uptake was expressed and with sex and age. Ten-year-old girls had the highest correlations, from r2= 0.48 (fV̇O2peak) to 0.65 (rV̇O2peak) between AT and V̇O2peak. The AT was found to be as valid as the 20-metre shuttle run test in estimating peak oxygen uptake, with a random measurement error of about 11% of mean values.