AUTHOR=Chan Jillian , Senior Hailey , Homitz Jessica , Cashin Niamh , Guers John J. TITLE=Individuals with a previous symptomatic COVID-19 infection have altered heart rate and blood pressure variability during acute exercise JOURNAL=Frontiers in Physiology VOLUME=Volume 14 - 2023 YEAR=2023 URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2023.1052369 DOI=10.3389/fphys.2023.1052369 ISSN=1664-042X ABSTRACT=As the number of COVID-19 cases begins to diminish it is important to turn our attention to any long-term issues that may be associated with a prior infection. Cardiovascular defects have been noted following prior SARS-CoV-2 infections. However, less is known about how a previous infection alters the cardiovascular response to exercise. Further, differences may exist during exercise between previously SARS-CoV-2 positive individuals who had symptoms (symptomatic) relative to those who did not have symptoms (asymptomatic). We hypothesized that previously symptomatic (S) COVID-19 recoveries have an altered cardiovascular response to acute exercise relative to both control (CON; never infected), and previously COVID-19 positive asymptomatic (AS) individuals. Methods: Twenty-seven four subjects (CON=9; AS=9; S=9) underwent 30 minutes of submaximal treadmill exercise. During exercise, blood pressure was recorded on the brachial artery every 5 minutes and 3-lead electrocardiography was measured continuously. Indirect indicators of autonomic nervous system health: heart rate variability and blood pressure variability were measured for each session. Baseline mean arterial pressure (MAP) was taken prior to exercise in seated, standing and supine positions. Blood pressure was similar (p>0.05) amongst all three groups. There were no differences between average heart rate (HR;CON=104 ± 4 BPM vs. AS=118 ±6 BPM vs. S=112± 3 BPM), mean arterial pressure (MAP;CON=108±4 mmHg vs. AS=105±13 mmHg vs. S=108±7 mmHg) or oxygen consumption (VO2) between groups during a bout of exercise. However, the standard deviation of the inter beat intervals of normal sinus beats, a measure of heart rate variability (HRV) (CON=138 ± 2.8ms vs. AS =156±6ms vs. S=77.7±11ms; p<0.05) and blood pressure variability (BPV; CON=5.18 ± 1.1 vs. AS=12.1 ± 0.88 mmHg vs. S=10.2 ±10.7 mmHg; p<0.05) were different in our S group. Further, when HRV was assessed in the frequency domain the very low frequency was different during exercise in the S group relative to the other groups. Collectively, these data suggest that a previous symptomatic SARS-CoV-2 infection may alter heart rate and blood pressure regulation during exercise.