AUTHOR=Tu Jiabin , Wu Bo , Xiu Jiaming , Deng Jiayi , Lin Shuqiong , Lu Jin , Yan Yanfang , Yu Pei , Zhu Jinlong , Chen Kaihong , Ding Shan , Chen Liling 

TITLE=Advanced lung cancer inflammation index is associated with long-term cardiovascular death in hypertensive patients: national health and nutrition examination study, 1999–2018

JOURNAL=Frontiers in Physiology

VOLUME=Volume 14 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2023.1074672

DOI=10.3389/fphys.2023.1074672

ISSN=1664-042X

ABSTRACT=Abstract
Background: Hypertension is one of the main causes of cardiovascular death. Inflammation was considered influential factors of cardiovascular (CVD) death in patients with hypertension. Advanced lung cancer inflammation index (ALI) is an index to assess inflammation, few studies have investigated the relationship between ALI and CVD death in hypertensive patients. 
Objective: The aim of this study was to investigate the association between ALI and long-term CVD death in hypertensive patients. 
Method: Data from the National Health and Nutrition Examination Survey (NHANES) 1999–2018 with mortality follow-up through December 31, 2019 were analyzed. ALI was calculated as BMI (kg/㎡) × serum albumin level (g/dL) / neutrophil to lymphocyte ratio (NLR). A total of 20,517 participants were evaluated. Patients were divided into three groups based on tertiles of ALI as follows: T1 (n=6,839), T2 (n=6,839), and T3 (n=6,839) groups. The relationship between ALI and long-term CVD death was assessed by survival curves and Cox regression analysis based on the NHANES recommended weights. 
Results: The median ALI value in this study was 61.9 [44.4, 84.6]. After full adjustment, the T2 group (hazard ratio [HR]: 0.59, 95% confidence interval [CI]: 0.50−0.69; P < 0.001) and T3 group (HR: 0.48, 95% CI: 0.39−0.58; P < 0.001) were found to have a significantly lower risk of CVD death compared to the T1 group
Conclusion: High levels of ALI were associated with reduced risk of CVD death in hypertensive patients