AUTHOR=Lin Suewei 

TITLE=The making of the Drosophila mushroom body

JOURNAL=Frontiers in Physiology

VOLUME=Volume 14 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2023.1091248

DOI=10.3389/fphys.2023.1091248

ISSN=1664-042X

ABSTRACT=The mushroom body (MB) is a computational center in the Drosophila brain. The intricate neural circuits of the MB enable it to store associative memories and process sensory and internal state information. The MB is composed of diverse types of neurons that are precisely assembled during development. Tremendous efforts have been made to unravel the molecular and cellular mechanisms that build the MB. However, we are still at the beginning of this challenging quest, with many key aspects of MB assembly remaining unexplored. In this review, I provide an in-depth overview of our current understanding of MB development and pertinent knowledge gaps.