AUTHOR=Liu Dongge , Yan Shuqi , Wang Pingwei , Chen Qianqian , Liu Yanping , Cui Jiajing , Liang Yujun , Ren Shuping , Gao Ying 

TITLE=Perfluorooctanoic acid (PFOA) exposure in relation to the kidneys: A review of current available literature

JOURNAL=Frontiers in Physiology

VOLUME=Volume 14 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2023.1103141

DOI=10.3389/fphys.2023.1103141

ISSN=1664-042X

ABSTRACT=Perfluorooctanoic acid (PFOA) is an artificial and nondegradable chemical，it is widely used due to its stable nature. It can enter into human body through food, drinking water, inhalation of household dust and contact with products containing perfluorooctanoic acid, and accumulate in the human body, causing potential harmful effects on human health. Based on the biodegradability and bioaccumulation of perfluorooctanoic acid in human body, people are increasingly concerned about the adverse effects of perfluorooctanoic acid exposure on kidneys. Research shows that kidney is the main accumulation organ of PFOA，PFOA can cause nephrotoxicity and produce adverse effects on kidney function, but the exact mechanism is still unknown. In this review, we summarized the relationship between PFOA exposure and kidney health，evaluated risks more clearly, and provided a theoretical basis for subsequent research.