AUTHOR=Silva Jairo Montemor Augusto , Antonio Ednei Luiz , Dos Santos Luis Felipe Neves , Serra Andrey Jorge , Feliciano Regiane Santos , Junior Jose Antonio Silva , Ihara Silvia Saiuli Miki , Tucci Paulo Jose Ferreira , Moises Valdir Ambrosio 

TITLE=Hypertrophy of the right ventricle by pulmonary artery banding in rats: a study of structural, functional, and transcriptomics alterations in the right and left ventricles

JOURNAL=Frontiers in Physiology

VOLUME=Volume 14 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2023.1129333

DOI=10.3389/fphys.2023.1129333

ISSN=1664-042X

ABSTRACT=Introduction:
Right ventricular remodeling with subsequent functional impairment can occur in some clinical conditions in adults and children. The triggering factors, the molecular mechanisms, and especially the evolution over time are still not well known. Left ventricular (LV) changes associated with right ventricular (RV) remodeling are also poorly understood.
 Objectives:
• To evaluate RV morphological, functional, and gene expression parameters in rats submitted to pulmonary artery banding compared to control rats, with the temporal evolution of these parameters.
• To analyze the influence of RV remodeling by pulmonary artery banding in rats and their controls over time on LV geometry, histology, gene expression, and functional performance.