AUTHOR=Jia Mingyuan , Wang Zhiyong , Hu Fengting 

TITLE=Causal relationship between physical activity and platelet traits: a Mendelian randomization study

JOURNAL=Frontiers in Physiology

VOLUME=15

YEAR=2024

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2024.1371638

DOI=10.3389/fphys.2024.1371638

ISSN=1664-042X

ABSTRACT=<p><bold>Introduction:</bold> The purpose of this study was to discuss the causal relationship between physical activity and platelet traits.</p><p><bold>Methods:</bold> A dataset from a large-scale European physical activity and platelet traits was collected by using Mendelian randomization of the study. For the analysis, the inverse variance weighting method, weighted median and MR-Egger were used to estimate causal effects. The sensitivity analyses were also performed using Cochran’s Q test, funnel plots and Leave-one-out analysis.</p><p><bold>Results:</bold> Light DIY, other exercises, strenuous sports, walking for pleasure were significantly associated with a decrease in platelet crit. But none of the heavy /light DIY was associated with increase in platelet crit. Other exercises and strenuous sports were associated with decrease in platelet count.</p><p><bold>Conclusion:</bold> Some types of physical activity have a causal relationship with platelet crit and platelet count. However, the types of physical activity we studied have not supported a causal relationship with mean platelet volume and platelet distribution width.</p>