AUTHOR=Dai Guokui , Cai Xiangsheng , Ye Chuanjiang , Zhang Yuzhen , Guan Ruoping 

TITLE=A cross-sectional study of factors associated with carotid atherosclerosis

JOURNAL=Frontiers in Physiology

VOLUME=Volume 15 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2024.1434173

DOI=10.3389/fphys.2024.1434173

ISSN=1664-042X

ABSTRACT=Objective To study the relationship between carotid atherosclerosis (CAS) and several indexes, and to provide a basis for the prevention and treatment of cardiovascular and cerebrovascular diseases. Methods 11028 adults who wereunderwent physical examinationat the Guangzhou Cadre and Talent Health Management Center from January 2023 to December 2023 were selected as research subjects.Retrospective analysis was used to understand the carotid atherosclerosis of the examined population, and retrospective analyze was used to understand the carotid atherosclerosis of the examined population and analyze the relationship with sex, age, blood pressure, blood glucose, blood lipids, renal function, 25 hydroxyvitamin D, neutrophil to lymphocyte count ratio (NLR), platelet to lymphocyte count ratio (PLR), systemic immune inflammation index (SII), monocyte count to high-density lipoprotein cholesterol ratio (MHR), triglyceride glucose body mass index (TyG BMI), insulin resistance metabolic index (METS-IR) and other indicators. Results Among 11028 subjects, the detection rate of carotid atherosclerotic thickening (CAT) was 12.00% and carotid atherosclerotic plaque (CAP) was 25.11%. The CAT and CAP detection rates in men were 13.32% and 28.78%, respectively, which were higher than the CAT detection rate of 8.28% and CAP detection rate of 14.80% in women, and the differences were statistically significant (both P < 0.001). Multivariate logistic regression analysis using TyG-BMI and METS-IR as two indicators were modeled separately, and the results showed that CAS was associated with increasing age, men, and systolic blood pressure. The area under the curve (AUC) was analyzed using the subject's work characteristics (ROC) curve in descending order of METS-IR, TyG-BMI, and MHR.The combination of the three indexes of sex, age, and METS-IR predicted atherosclerosis with the highest AUC values. Conclusion Carotid atherosclerosis is highly prevalent in men, and with age, the elevation of systolic blood pressure, fasting glucose, MHR, and TyG-BMI (or METS-IR) are independent influences on carotid atherosclerosis.The three indexes of MHR, TyG-BMI, and METS-IR, respectively, in combination with sex and age, can be used as a new and effective index to predict CAS.