AUTHOR=Brzezińska Paulina , Mieszkowski Jan , Stankiewicz Błażej , Kowalik Tomasz , Reczkowicz Joanna , Niespodziński Bartłomiej , Durzyńska Aleksandra , Kowalski Konrad , Borkowska Andżelika , Antosiewicz Jędrzej , Kochanowicz Andrzej 

TITLE=Direct effects of remote ischemic preconditioning on post-exercise-induced changes in kynurenine metabolism

JOURNAL=Frontiers in Physiology

VOLUME=Volume 15 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2024.1462289

DOI=10.3389/fphys.2024.1462289

ISSN=1664-042X

ABSTRACT=PurposeTryptophan (TRP) degradation through the kynurenine pathway is responsible for converting 95% of free TRP into kynurenines, which modulate skeletal muscle bioenergetics, immune and central nervous system activity. Therefore, changes in the kynurenines during exercise have been widely studied but not in the context of the effects of remote ischemic preconditioning (RIPC). In this study, we analyzed the effect of 14-day RIPC training on kynurenines and TRP in runners after running intervals of 20 × 400 m.MethodsIn this study, 27 semi-professional long-distance runners were assigned to two groups: a RIPC group performing 14 days of RIPC training (n = 12), and a placebo group, SHAM (n = 15). Blood was collected for analysis before, immediately after, and at 6 h and 24 h after the run.ResultsAfter the 14-day RIPC/SHAM intervention, post hoc analysis showed a significantly lower concentration of XANA and kynurenic acid to kynurenine ratio (KYNA/KYN) in the RIPC group than in the SHAM group immediately after the running test. Conversely, the decrease in serum TRP levels was higher in the RIPC population.ConclusionRIPC modulates post-exercise changes in XANA and TRP levels, which can affect brain health, yet further research is needed.