AUTHOR=Deng Ke , Pei Mingxin , Li Beibei , Yang Nanqi , Wang Zijian , Wan Xinchi , Zhong Zhiying , Yang Zhiyi , Chen Yanling 

TITLE=Signal pathways involved in contrast-induced acute kidney injury

JOURNAL=Frontiers in Physiology

VOLUME=Volume 15 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2024.1490725

DOI=10.3389/fphys.2024.1490725

ISSN=1664-042X

ABSTRACT=Contrast-induced acute kidney injury (CI-AKI) has emerged as a global public health concern, ranking as the third most prevalent cause of hospital-acquired acute kidney injury, which is related to adverse outcomes. However, its precise pathogenesis remains elusive. Consequently, researchers are dedicated to uncovering CI-AKI’s pathophysiology and signaling pathways, including inflammation, oxidative stress, apoptosis, and ferroptosis, to improve prevention and treatment. This review thoroughly analyzes the signaling pathways and their interactions associated with CI-AKI, assesses the impact of various research models on pathway analysis, and explores more precise targeted treatment and prevention approaches. Aims to furnish a robust theoretical foundation for the molecular mechanisms underpinning clinical treatments.