AUTHOR=Li Xinyang , Li Changfei , Liu Tiemei 

TITLE=Overview of detection methods of fetomaternal haemorrhage

JOURNAL=Frontiers in Physiology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2025.1445757

DOI=10.3389/fphys.2025.1445757

ISSN=1664-042X

ABSTRACT=Fetomaternal haemorrhage is the same immunity that occurs when foetal and maternal blood are incompatible. It is critical to accurately quantify maternal haemorrhaging in order to prevent hemolytic disease in the infant. At this time, the rosette test and K-B test are the most frequently used techniques for detecting foetal red blood cells in the mother’s blood. However, the sensitivity of the rosette test is low, and due to its complex operation and high subjectivity, the K-B test cannot be used as a routine clinical detection method. This review therefore focuses primarily on the clinical landscape and future prospects of methods for detecting fetomaternal haemorrhage. In a general sense, this may bring to light the most promising strategy and encourage the development of technology for fetomaternal haemorrhage in order to guarantee the early detection and prevention of hemolytic disease in newborns.