AUTHOR=Liu Yang-Yang , Jiang Shao-Peng , Wang Ying-Bin TITLE=Artificial intelligence optimizes the standardized diagnosis and treatment of chronic sinusitis JOURNAL=Frontiers in Physiology VOLUME=Volume 16 - 2025 YEAR=2025 URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2025.1522090 DOI=10.3389/fphys.2025.1522090 ISSN=1664-042X ABSTRACT=BackgroundStandardised management of chronic sinusitis (CRS) is a challenging but vital area of research. Not only is accurate diagnosis and individualised treatment plans required, but post-treatment chronic disease management is also indispensable. With the development of artificial intelligence (AI), more “AI + medical” application models are emerging. Many AI-assisted systems have been applied to the diagnosis and treatment of CRS, providing valuable solutions for clinical practice.ObjectiveThis study summarises the research progress of various AI-assisted systems applied to the clinical diagnosis and treatment of CRS, focusing on their role in imaging and pathological diagnosis and prognostic prediction and treatment.MethodsWe used PubMed, Web of Science, and other Internet search engines with “artificial intelligence”、“machine learning” and “chronic sinusitis” as the keywords to conduct a literature search for studies from the last 7 years. We included literature eligible for AI application to CRS diagnosis and treatment in our study, excluded literature outside this scope, and categorized it according to its clinical application to CRS diagnosis, treatment, and prognosis prediction. We provide an overview and summary of current advances in AI to optimize the diagnosis and treatment of CRS, as well as difficulties and challenges in promoting standardization of clinical diagnosis and treatment in this area.ResultsThrough applications in CRS imaging and pathology diagnosis, personalised medicine and prognosis prediction, AI can significantly reduce turnaround times, lower diagnostic costs and accurately predict disease outcomes. However, a number of challenges remain. These include a lack of AI product standards, standardised data, difficulties in collaboration between different healthcare providers, and the non-interpretability of AI systems. There may also be data privacy issues involved. Therefore, more research and improvements are needed to realise the full potential of AI in the diagnosis and treatment of CRS.ConclusionOur findings inform the clinical diagnosis and treatment of CRS and the development of AI-assisted clinical diagnosis and treatment systems. We provide recommendations for AI to drive standardisation of CRS diagnosis and treatment.