AUTHOR=Chen Guanjun , Li Yulan , Wei Shirui , Wang Xinyu , Kuang Zheshu , Guo Weiming , Qin Jianbin , Huang Tianjun , Li Youlin , Zhu Chunjiang 

TITLE=Role of gut microbiota in thalassemia: a review of therapeutic prospects

JOURNAL=Frontiers in Physiology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2025.1523448

DOI=10.3389/fphys.2025.1523448

ISSN=1664-042X

ABSTRACT=In recent years, the study of gut microbiota has gradually become a research hotspot in the field of medicine, as gut microbiota dysbiosis is closely related to various diseases. Thalassemia, as a hereditary hemoglobinopathy, has a complex pathophysiological mechanism, and traditional treatment methods show limited efficacy. With a deeper understanding of the gut microbiome, researchers have begun to focus on its role in the pathogenesis of thalassemia and its therapeutic effects. This article aims to review the role of gut microbiota in thalassemia and its potential therapeutic prospects, analyze the latest research findings, and explore the impact and mechanisms of gut microbiota on patients with thalassemia, with the goal of providing new ideas and directions for future research and clinical treatment of thalassemia.