AUTHOR=Alasmari Sultan , AlGhamdi Rayed , Tejani Ghanshyam G. , Kumar Sharma Sunil , Mousavirad Seyed Jalaleddin 

TITLE=Federated learning-based multimodal approach for early detection and personalized care in cardiac disease

JOURNAL=Frontiers in Physiology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2025.1563185

DOI=10.3389/fphys.2025.1563185

ISSN=1664-042X

ABSTRACT=IntroductionHeart disease remains a leading cause of mortality globally, and early detection is critical for effective treatment and management. However, current diagnostic techniques often suffer from poor accuracy due to misintegration of heterogeneous health data, limiting their clinical usefulness.MethodsTo address this limitation, we propose a privacy-preserving framework based on multimodal data analysis and federated learning. Our approach integrates cardiac images, ECG signals, patient records, and nutrition data using an attention-based feature fusion model. To preserve patient data privacy and ensure scalability, we employ federated learning with locally trained Deep Neural Networks optimized using Stochastic Gradient Descent (SGD-DNN). The fused feature vectors are input into the SGD-DNN for cardiac disease classification.ResultsThe proposed framework demonstrates high accuracy in cardiac disease detection across multiple datasets: 97.76% on Database 1, 98.43% on Database 2, and 99.12% on Database 3. These results indicate the robustness and generalizability of the model.DiscussionOur framework enables early diagnosis and personalized lifestyle recommendations while maintaining strict data confidentiality. The combination of federated learning and multimodal feature fusion offers a scalable, privacy-centric solution for heart disease management, with strong potential for real-world clinical implementation.