AUTHOR=Chau Ngan-Khanh , Park Eun-Kee , Choi Sanghun 

TITLE=Longitudinal analysis of coal workers’ pneumoconiosis using enhanced resolution-computed tomography images: unveiling patterns in lung structure, function, and clinical correlations

JOURNAL=Frontiers in Physiology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2025.1578058

DOI=10.3389/fphys.2025.1578058

ISSN=1664-042X

ABSTRACT=RationalePneumoconiosis, caused by prolonged exposure to mineral dust, leads to progressive structural and functional lung alterations. Quantitative computed tomography (qCT) has emerged as a critical tool for assessing these changes, yet there is limited research on the longitudinal patterns in pneumoconiosis patients.MethodsThis study examined a cohort of 31 former coal workers with pneumoconiosis over a 1-year period. Inspiratory qCT images were enhanced using a deep learning-based super-resolution model and then processed to extract lung functional and airway structural metrics. A non-rigid image registration process was performed with baseline images as fixed and follow-up images as moving. Registration-derived metrics, including anisotropic deformation index (ADI), slab rod index (SRI), and Jacobian (J), were extracted to quantify regional deformation longitudinally. Pulmonary function tests, including forced expiratory volume in one second (FEV1) and forced vital capacity (FVC), were recorded at both time points to assess functional decline.ResultsThe study identified significant airway changes in angles, diameters, and geometry, with a decrease in normal lung tissue in the right upper lobe. Blood vessel volumes declined, indicating vascular remodeling. Registration metrics revealed regional heterogeneity, with higher ADI and SRI values and localized volume loss (J) in the lower lobes. FEV1/FVC progression correlated positively with tracheal angle, emphysema, and consolidation but negatively with normal lung tissue, semi-consolidation, and fibrosis. ADI, SRI, and J were associated with structural deformation, airway remodeling, and parenchymal loss, linking these changes to lung function decline.ConclusionqCT imaging and registration metrics effectively monitor structural and functional lung changes in pneumoconiosis. Registering baseline and follow-up inspiration images offers additionally valuable insights into disease progression.