AUTHOR=Xiang Jun-Zhi , Wang Qin-Yong , Fang Zhi-Bin , Esquivel James A. , Su Zhi-Xian TITLE=A multi-modal deep learning approach for stress detection using physiological signals: integrating time and frequency domain features JOURNAL=Frontiers in Physiology VOLUME=Volume 16 - 2025 YEAR=2025 URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2025.1584299 DOI=10.3389/fphys.2025.1584299 ISSN=1664-042X ABSTRACT=ObjectiveThis study aims to develop a multimodal deep learning-based stress detection method (MMFD-SD) using intermittently collected physiological signals from wearable devices, including accelerometer data, electrodermal activity (EDA), heart rate (HR), and skin temperature. Given the unique demands and high-intensity work environment of the nursing profession, stress measurement in nurses serves as a representative case, reflecting stress levels in other high-pressure occupations.MethodsWe propose a multimodal deep learning framework that integrates time-domain and frequency-domain features for stress detection. To enhance model robustness and generalization, data augmentation techniques such as sliding window and jittering are applied. Feature extraction includes statistical features derived from raw time-domain signals and frequency-domain features obtained via Fast Fourier Transform (FFT). A customized deep learning architecture employs convolutional neural networks (CNNs) to process time-domain and frequency-domain features separately, followed by fully connected layers for final classification. To address class imbalance, the Synthetic Minority Over-sampling Technique (SMOTE) is utilized. The model is trained and evaluated on a multimodal physiological signal dataset with stress level labels.ResultsExperimental results demonstrate that the MMFD-SD method achieves outstanding performance in stress detection, with an accuracy of 91.00% and an F1-score of 0.91. Compared to traditional machine learning classifiers such as logistic regression, random forest, and XGBoost, the proposed method significantly improves both accuracy and robustness. Ablation studies reveal that the integration of time-domain and frequency-domain features plays a crucial role in enhancing model performance. Additionally, sensitivity analysis confirms the model’s stability and adaptability across different hyperparameter settings.ConclusionThe proposed MMFD-SD model provides an accurate and robust stress detection approach by integrating time-domain and frequency-domain features. Designed for occupational environments with intermittent data collection, it effectively addresses real-world stress monitoring challenges. Future research can explore the fusion of additional modalities, real-time stress detection, and improvements in model generalization to enhance its practical applicability.