AUTHOR=Schmitz Gerald 

TITLE=Case report: Biphasic autonomic response in decompression sickness: HRV and sinoatrial findings

JOURNAL=Frontiers in Physiology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2025.1605779

DOI=10.3389/fphys.2025.1605779

ISSN=1664-042X

ABSTRACT=BackgroundDecompression sickness (DCS) may involve neurological and cardiovascular systems, but cardiac autonomic dysfunction is rarely documented. Heart rate variability (HRV) can provide insight into autonomic modulation in such cases, particularly when incorporating advanced nonlinear and dynamic techniques.CaseWe present a 35-year-old recreational diver who developed neurological DCS and persistent bradycardia following multiple consecutive dives. Neurological symptoms resolved with hyperbaric oxygen therapy (HBOT), but bradyarrhythmias persisted, prompting continuous monitoring.MethodsHRV was assessed using time-domain, frequency-domain, nonlinear, and dynamic analyses during HBOT and over two 24-h Holter recordings. Principal Dynamic Mode (PDM) analysis was employed to characterize autonomic control dynamics beyond conventional spectral markers.ResultsDuring HBOT, the patient exhibited pronounced parasympathetic activity (RMSSD: 243 m; HF power: 8,656 m2; SD1: 172 m). Post-treatment, a shift toward sympathovagal imbalance was observed, with the LF/HF ratio rising from 1.53 to 3.80. Despite high total HRV power (38,549 m2 during HBOT), SD1/SD2 ratio declined from 0.52 to 0.12, suggesting selective vagal withdrawal. PDM analysis showed a low PDM2/PDM1 ratio (0.42), consistent with preserved beat-to-beat vagal responsiveness but impaired long-range autonomic integration.ConclusionThis case illustrates a biphasic autonomic pattern in DCS—initial parasympathetic dominance followed by sympathetic tilt and desynchronization. Advanced nonlinear and dynamic HRV analysis revealed regulatory disturbances not captured by traditional methods, supporting its role in post-dive assessment and autonomic monitoring.