AUTHOR=Lin Zijin , Pandol Stephen , Apte Minoti , Jiang Yi 

TITLE=Navigating chronic pancreatitis pain: a pathophysiological and therapeutic overview

JOURNAL=Frontiers in Physiology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2025.1622845

DOI=10.3389/fphys.2025.1622845

ISSN=1664-042X

ABSTRACT=Pain management in chronic pancreatitis (CP) patients remains a major challenge, largely due to complex and refractory pain. Such pain detrimentally impacts patients by reducing quality of life, limiting daily activities, increasing psychological distress, necessitating frequent hospitalizations, and contributing to opioid dependence and socioeconomic burden. This review delineates the multifaceted nature of CP-related pain, highlighting the roles of neurogenic inflammation, maladaptive neuroplasticity, and disrupted pain modulation pathways. Current management strategies are multidisciplinary, encompassing lifestyle modification, pharmacologic therapies, endoscopic and surgical interventions, and nerve-targeted procedures (e.g., celiac plexus blocks and neurolysis). Advances in genetics, bioinformatics and biomarker research have further enhanced our understanding of CP-related pain pathogenesis, paving the way for precision medicine approaches. This review highlights current evidence and emerging innovations in the evolving landscape of CP-related pain management, emphasizing the importance of tailored and interdisciplinary care to address the intricate mechanism of CP-related pain and improve patient outcomes.