AUTHOR=You Guopeng , Xie Jinwen , Tong Wei , Zhao Shaocong 

TITLE=The new perspective of cardiac exercise rehabilitation: based on integrative physiology

JOURNAL=Frontiers in Physiology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2025.1651589

DOI=10.3389/fphys.2025.1651589

ISSN=1664-042X

ABSTRACT=Cardiovascular diseases (CVDs) are the world’s leading cause of death, but there’s a gap between scientific research and real-world treatment. Exercise is a safe and effective way to prevent and manage CVDs, yet putting it into practice faces many challenges. This review shows how exercise protects the heart by improving metabolism, reducing inflammation and cell damage, and strengthening connections between heart cells and blood vessels. Exercise establishes a multi-organ defense network involving remote organs including the brain, skeletal muscle, adipose tissue, liver, and kidneys. To bridge the gap between research and clinical use, future efforts should focus on developing exercise-like drugs, personalized workout plans, and remote rehabilitation programs.