Frontiers in Physiology | Integrative Physiology section | New and Recent Articles https://www.frontiersin.org/journals/physiology/sections/integrative-physiology RSS Feed for Integrative Physiology section in the Frontiers in Physiology journal | New and Recent Articles en-us Frontiers Feed Generator,version:1 2026-05-13T16:29:24.442+00:00 60 https://www.frontiersin.org/articles/10.3389/fphys.2026.1811438 https://www.frontiersin.org/articles/10.3389/fphys.2026.1811438 <![CDATA[Effect of acupuncture on monoaminergic neurotransmitters in animal models of vascular dementia: a preclinical systematic review and meta-analysis]]> 2026-05-11T00:00:00Z Systematic Review Lixiang GanYuqing FanDongmin LiuJialing ZhengJize HanChuyu DengXiaorong TangNenggui XuZhennan Wu https://www.frontiersin.org/articles/10.3389/fphys.2026.1811508 https://www.frontiersin.org/articles/10.3389/fphys.2026.1811508 <![CDATA[Advancing the 3Rs in bone tissue engineering: emerging in vitro, in silico, and refined in vivo strategies]]> 2026-05-11T00:00:00Z Review Adelaide L. CagleAfton K. LimbergAmritha AnupAleyna E. La CroixKatherine R. Hixon https://www.frontiersin.org/articles/10.3389/fphys.2026.1741526 https://www.frontiersin.org/articles/10.3389/fphys.2026.1741526 <![CDATA[Is there a link between fascia and cancer? From potential mechanisms to future treatment options]]> 2026-05-08T00:00:00Z Review Stephanie OttoWerner Klingler https://www.frontiersin.org/articles/10.3389/fphys.2026.1808008 https://www.frontiersin.org/articles/10.3389/fphys.2026.1808008 <![CDATA[A study on brain waves with electroencephalogram through the appreciation of virtual reality K-pop: a revised analysis with multiple comparison corrections]]> 2026-05-08T00:00:00Z Original Research Taeseung ParkHyunsoo KimDeok Su Yoo https://www.frontiersin.org/articles/10.3389/fphys.2026.1807587 https://www.frontiersin.org/articles/10.3389/fphys.2026.1807587 <![CDATA[Effectiveness of non-pharmacological therapies in complementary and alternative medicine on improving fatigue levels, oxidative stress, inflammation, and endocrine levels in animal models of chronic fatigue-like conditions: a systematic review and network meta-analysis]]> 2026-05-07T00:00:00Z Systematic Review Shumeng RenJingyuan WeiShan ZhaoLinghua LiJingshi ZhangChaoqun YanJun Wang https://www.frontiersin.org/articles/10.3389/fphys.2026.1851497 https://www.frontiersin.org/articles/10.3389/fphys.2026.1851497 <![CDATA[Correction: Exercise and the hepatic sirtuin network: rethinking the research focus on SIRT1, SIRT3, and SIRT6]]> 2026-05-05T00:00:00Z Correction Jun Woo Kwon https://www.frontiersin.org/articles/10.3389/fphys.2026.1785483 https://www.frontiersin.org/articles/10.3389/fphys.2026.1785483 <![CDATA[Physiological responses and adaptive mechanisms of amphibians and reptiles to multiple interacting environmental stressors: an integrative review]]> 2026-04-30T00:00:00Z Review Muammer Kurnaz 1000 s/cm in desert-adapted reptiles. Synergistic interactions between thermal and hydric stress significantly amplify vulnerability, particularly in dehydration scenarios that reduce critical thermal limits. Chemical pollutants, including heavy metals and pesticides, cause developmental abnormalities (535% increase in malformation frequency), immunosuppression, and endocrine disruption across multiple life stages. Emerging infectious diseases, particularly chytridiomycosis (Batrachochytrium dendrobatidis and B. salamandrivorans) and ranaviruses, drive mass mortality events globally, with co-infections exacerbating population declines. Climate change intensifies disease susceptibility through stress-mediated immunosuppression and altered pathogen dynamics. Adaptive capacity varies markedly among species. While amphibians exhibit strong phenological responses (2-4× greater than other taxa), genetic adaptation potential remains limited by narrow dispersal abilities and habitat fragmentation. Microhabitat buffering can reduce thermal extremes by several degrees but depends critically on habitat structural integrity. This review demonstrates that the pace of anthropogenic change challenges the adaptive capacity of most species, necessitating integrated conservation strategies including microhabitat preservation, climate corridor establishment, pollution mitigation, disease surveillance, and ex-situ conservation programs.]]> https://www.frontiersin.org/articles/10.3389/fphys.2026.1813708 https://www.frontiersin.org/articles/10.3389/fphys.2026.1813708 <![CDATA[25 years of applying the 3Rs principles in safety pharmacology: success stories and future perspectives]]> 2026-04-27T00:00:00Z Review Katayoun DerakhchanKimberly RockleyMatthias GossmannRaafat FaresEric DelpyYasunari KandaElisa PassiniColleen M. PikeJanette TurnerAnnie Delaunois https://www.frontiersin.org/articles/10.3389/fphys.2026.1818880 https://www.frontiersin.org/articles/10.3389/fphys.2026.1818880 <![CDATA[Changes in cardio-respiratory-vascular coupling dynamics across altitude gradients: a shift from linear synchrony to nonlinear complexity]]> 2026-04-23T00:00:00Z Original Research Hongyun LiuShijing WuPing ZhanXiaohua YuYiming KuangYi HanHongyue ZuGuojing WangWeidong Wang https://www.frontiersin.org/articles/10.3389/fphys.2026.1808472 https://www.frontiersin.org/articles/10.3389/fphys.2026.1808472 <![CDATA[Bridging physiology and psychology: a new framework for teaching homeostasis]]> 2026-04-15T00:00:00Z Perspective Suzan Kamel-ElSayedNermien E. WalyChangiz Mohiyeddini https://www.frontiersin.org/articles/10.3389/fphys.2026.1802999 https://www.frontiersin.org/articles/10.3389/fphys.2026.1802999 <![CDATA[Efficacy and safety of gabapentinoid combination therapy versus monotherapy for the treatment of neuropathic pain]]> 2026-04-13T00:00:00Z Original Research Dandan LiYang HeZhiqiang FanZhen ChenGuiming DengLinqi Ouyang https://www.frontiersin.org/articles/10.3389/fphys.2026.1791778 https://www.frontiersin.org/articles/10.3389/fphys.2026.1791778 <![CDATA[High intellectual ability and the gut-brain-sex steroids axis: a perspective on cognitive and emotional diversity]]> 2026-04-13T00:00:00Z Perspective Ítalo M. UrrutiaNicolás PlazaFelipe MoragaConstanza Griffiths-SanhuezaDiliana Pérez-ReytorEduardo KarahanianSebastián Ramírez-ArayaAna KinkeadMaría Paz GómezKatherine Garcia https://www.frontiersin.org/articles/10.3389/fphys.2026.1794215 https://www.frontiersin.org/articles/10.3389/fphys.2026.1794215 <![CDATA[Molecular mechanism of Danshen injection in treating endometrial fibrosis induced by intrauterine adhesions via the LAMC2-CD44-TGF-β1-SMAD2/3 signaling pathway]]> 2026-04-10T00:00:00Z Original Research Sisi TangRenzhi HuShuangyan WengMei Luo https://www.frontiersin.org/articles/10.3389/fphys.2026.1795656 https://www.frontiersin.org/articles/10.3389/fphys.2026.1795656 <![CDATA[The fascial-interstitial system and the sanjiao-mocou system: an analogy-based hypothesis for the anatomical basis of meridian pathways]]> 2026-03-27T00:00:00Z Review Yu XiaYuxin JiaHui QuQianxue WeiLimei YanXiuqin Li https://www.frontiersin.org/articles/10.3389/fphys.2026.1801306 https://www.frontiersin.org/articles/10.3389/fphys.2026.1801306 <![CDATA[Myofascial release and fascial-targeted mechanical interventions in musculoskeletal rehabilitation: mechanisms, modalities, and integrative physiology]]> 2026-03-27T00:00:00Z Review Yuqing GaoDongxu Gao https://www.frontiersin.org/articles/10.3389/fphys.2026.1788828 https://www.frontiersin.org/articles/10.3389/fphys.2026.1788828 <![CDATA[Short-term cigarette smoke exposure aggravates oxidative stress and airway inflammation induced by lipopolysaccharides]]> 2026-03-19T00:00:00Z Original Research Ziyao LiangZhihang LiuWenchao PanLong FanJingyu QuanLin LinLei WuXuhua Yu https://www.frontiersin.org/articles/10.3389/fphys.2025.1600369 https://www.frontiersin.org/articles/10.3389/fphys.2025.1600369 <![CDATA[Impact of cricothyroid membrane puncture anesthesia on elderly patients undergoing endotracheal intubation after anesthesia induction: a clinical study]]> 2026-03-11T00:00:00Z Original Research Yanbing WangHongchuan ZhaoYanjiao LiangXiaoli LiXiao BiHao Lian 0.05). The study group had lower rates of hypotension and vasoactive drug use compared with the control group (P < 0.05), as well as a lower incidence of coughing during extubation (P < 0.05). At T0, heart rate (HR), systolic blood pressure (SBP), mean arterial pressure (MAP), and SpO2 did not differ significantly (P > 0.05). At T1-T3, HR, SBP, and MAP were significantly lower in the study group (P < 0.05), with no significant differences in SpO2 (P > 0.05). Total adverse event rates were similar between groups (P > 0.05).ConclusionCMP surface anesthesia following anesthesia induction in elderly patients provides favorable clinical effects by improving hemodynamic stability and reducing coughing during emergence, without increasing adverse events.]]> https://www.frontiersin.org/articles/10.3389/fphys.2026.1784015 https://www.frontiersin.org/articles/10.3389/fphys.2026.1784015 <![CDATA[How should we teach homeostasis? Filling the gaps and envisioning the future]]> 2026-03-02T00:00:00Z Conceptual Analysis Serena Y. KuangAkshata R. Naik https://www.frontiersin.org/articles/10.3389/fphys.2026.1809357 https://www.frontiersin.org/articles/10.3389/fphys.2026.1809357 <![CDATA[Editorial: Exploring the physiological and molecular benefits of physical exercise in cardiovascular diseases]]> 2026-02-25T00:00:00Z Editorial Alex Cleber Improta-CariaRoque Aras Júnior https://www.frontiersin.org/articles/10.3389/fphys.2026.1740223 https://www.frontiersin.org/articles/10.3389/fphys.2026.1740223 <![CDATA[mRNA expression profiling and pathway analysis of chronic intermittent hypoxia–induced pancreatic injury in ob/ob mice]]> 2026-02-25T00:00:00Z Original Research Yaopeng GuoShengquan HuangJiayi LinChaowei LiRuhai LinQingshi Chen