AUTHOR=Sweetlove Lee J., Ratcliffe R. George TITLE=Flux-Balance Modeling of Plant Metabolism JOURNAL=Frontiers in Plant Science VOLUME=Volume 2 - 2011 YEAR=2011 URL=https://www.frontiersin.org/journals/plant-science/articles/10.3389/fpls.2011.00038 DOI=10.3389/fpls.2011.00038 ISSN=1664-462X ABSTRACT=

Flux-balance modeling of plant metabolic networks provides an important complement to 13C-based metabolic flux analysis. Flux-balance modeling is a constraints-based approach in which steady-state fluxes in a metabolic network are predicted by using optimization algorithms within an experimentally bounded solution space. In the last 2 years several flux-balance models of plant metabolism have been published including genome-scale models of Arabidopsis metabolism. In this review we consider what has been learnt from these models. In addition, we consider the limitations of flux-balance modeling and identify the main challenges to generating improved and more detailed models of plant metabolism at tissue- and cell-specific scales. Finally we discuss the types of question that flux-balance modeling is well suited to address and its potential role in metabolic engineering and crop improvement.