AUTHOR=Yao Qiuming , Bollinger Curtis , Gao Jianjiong , Xu Dong , Thelen Jay J.

TITLE=P3DB: An Integrated Database for Plant Protein Phosphorylation

JOURNAL=Frontiers in Plant Science

VOLUME=Volume 3 - 2012

YEAR=2012

URL=https://www.frontiersin.org/journals/plant-science/articles/10.3389/fpls.2012.00206

DOI=10.3389/fpls.2012.00206

ISSN=1664-462X

ABSTRACT=Protein phosphorylation is widely recognized as the most pervasive, enzyme-catalyzed post-translational modification in eukaryotes.  In particular, plants have purloined this signaling mechanism as evidenced by the two-fold higher frequency of protein kinases within the genome compared to other eukaryotes.  While all aspects of plant protein phosphorylation research have grown in the past ten years; phosphorylation site mapping using high-resolution mass spectrometry has grown exponentially.  In Arabidopsis alone there are thousands of experimentally-determined phosphorylation sites.  To archive these events in a user-intuitive format we have developed P3DB, The Plant Protein Phosphorylation Database (p3db.org).  This database is a repository for plant protein phosphorylation site data, currently hosting information on 32,963 non-redundant sites collated from 23 experimental studies from seven plant species.  These data can be queried for a protein-of-interest using an integrated BLAST function to query similar sequences with known phosphorylation sites among the multiple plants currently investigated.  Thus, this resource can help identify functionally-conserved phosphorylation sites in plants using a multi-system approach.